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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Theoretical examination of aggregation effect on the dielectric characteristics of spherical cellular suspension.
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Theoretical examination of aggregation effect on the dielectric characteristics of spherical cellular suspension.

机译：聚集作用对球形细胞悬浮液介电特性的理论研究。

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摘要

Dielectric dispersion analysis of cellular suspension is generally based on the analogy to equivalent periodic material made up of identical inclusions. However, under true physiological conditions, when coupling and aggregation events usually occur, this analogy can introduce severe errors when attempting to probe the dielectric characteristics of the suspended fraction. In the framework of this study, a theoretical examination of the effect of aggregation on the dielectric characteristics of spherical cellular suspension is presented. Here, small clusters of coupled and fused (gap connected) shelled spheres were used to imitate the presence of aggregates when suspended in a homogenous suspension of spherical cells. The permittivity spectra of the aggregate-cell mixtures were numerically calculated by applying computational solution of complex potential problem using 3D Boundary Element Method. The dispersion characteristics of the mixtures have been determined as function of both aggregates shape andconcentration. Those reveal significant deviations in comparison to the characteristics of homogenous cellular suspension. Quantitative analyses of the induced fields and transmembrane potential gradients of the interacted cells suggest that those deviations are mainly induced due to changes occur on the polarization state of the membranes.
机译：细胞悬浮液的介电弥散分析通常是基于类似于由相同内含物组成的等效周期材料的。但是，在真实的生理条件下，通常会发生偶联和聚集事件，当试图探测悬浮部分的介电特性时，这种类比会引入严重的错误。在这项研究的框架内，提出了对聚集作用对球形细胞悬浮液介电特性影响的理论研究。在这里，耦合和融合（间隙连接）的带壳球体的小簇被用来模拟当悬浮在球形细胞的同质悬浮液中时聚集体的存在。通过使用3D边界元方法应用复杂电势问题的计算解，对聚集体-细胞混合物的介电常数谱进行数值计算。已经确定了混合物的分散特性是聚集体形状和浓度的函数。与同质细胞悬浮液的特征相比，那些显示出明显的偏差。对相互作用细胞的感应场和跨膜电位梯度的定量分析表明，这些偏差主要是由于膜的极化状态发生变化而引起的。

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