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首页> 外文期刊>Journal of Neuroscience Research >Acute morphine administration increases extracellular DA levels in the rat lateral septum by decreasing the GABAergic inhibitory tone in the ventral tegmental area.
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Acute morphine administration increases extracellular DA levels in the rat lateral septum by decreasing the GABAergic inhibitory tone in the ventral tegmental area.

机译：急性吗啡给药可通过降低腹侧被盖区的GABA抑制音来增加大鼠外侧隔中的细胞外DA水平。

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摘要

We studied the effect of an acute systemic administration of morphine and of a local intra-ventral tegmental area (VTA) infusion of the same drug on extracellular levels of dopamine (DA) in the lateral septum (LS) by in vivo microdialysis in anesthetized rats. The extracellular levels of 5-hydroxytryptamine (5-HT) were also measured in all dialysate samples. The acute systemic administration of morphine dose-dependently increased extracellular levels of DA but not of 5-HT in the LS, in the absence or presence of fluoxetine. This morphine effect was antagonized by the previous administration of naloxone, a specific opioid antagonist. The local infusion of morphine in the VTA also induced a significant increase of the extracellular levels of DA in the LS, concomitantly with a decrease of gamma-aminobutyric acid (GABA) extracellular levels in the VTA itself. Intriguingly, the LS extracellular levels of DA returned to basal values before the VTA GABA extracellular levels recovered. Our results show for thefirst time that an acute administration of morphine increases DA extracellular levels in the LS. The results also suggest that DA cells in the VTA and innervating the LS are under an inhibitory GABAergic tone sensitive to morphine. Taken together, our neurochemical data and previous studies involving LS DA in stress-related behavior support the hypothesis that DA in the LS plays a significant role in addictive behavior. The participation of LS DA and 5-HT systems in stress-induced relapse to drug seeking should be studied further.
机译：我们通过麻醉的大鼠体内微透析研究了吗啡的急性全身给药和局部腹膜内被盖区（VTA）输注相同药物对外侧隔（LS）中多巴胺（DA）细胞外水平的影响。 。还测量了所有透析液样品中5-羟基色胺（5-HT）的细胞外水平。在不存在或存在氟西汀的情况下，吗啡的急性全身给药剂量依赖性地增加了LS中DA的细胞外水平，但没有升高5-HT。先前服用纳洛酮（一种特定的阿片类拮抗剂）可对抗吗啡作用。在VTA中局部注入吗啡也导致LS中DA的细胞外水平显着增加，同时VTA自身中的γ-氨基丁酸（GABA）细胞外水平降低。有趣的是，DA的LS细胞外水平恢复到VTA GABA细胞外水平恢复之前的基础值。我们的结果首次表明吗啡的急性给药会增加LS中DA的细胞外水平。结果还表明，VTA和神经支配的LS中的DA细胞处于对吗啡敏感的抑制性GABA能状态。综上所述，我们的神经化学数据和有关LS DA与应激相关行为的先前研究均支持LS DA在成瘾行为中起重要作用的假说。 LS DA和5-HT系统在应激诱导的寻求药物复发中的参与应进一步研究。

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