...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of opioid management >Interpretation of oxycodone concentrations in oral fluid
【24h】

Interpretation of oxycodone concentrations in oral fluid

机译：口服液中羟考酮浓度的解释

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: The purpose of this retrospective study was to compare oxycodone concentrations in saliva and whole blood with a view to propose therapeutic concentrations in oral fluid. Oral fluid is an easy specimen to collect with several advantages over urine, including ease of collection and difficulty of adulteration. As oral fluid is a reflection of free drug circulating in the blood, drug concentrations in saliva are more closely related to blood levels than urine concentrations. The number of testing laboratories offering the analysis of prescription pain medications in urine has increased significantly over the last few years, along with the overuse and abuse of pain killing drugs, specifically oxycodone. Hence, the utility of oral fluid analysis in this field was assessed. Design: Paired specimens of blood and oral fluid were retrospectively studied in an attempt to establish a range for oxycodone concentrations in oral fluid reflective of therapeutic intake. Twenty-three paired oral fluid-blood specimens were studied. Oral fluid samples had been collected with the Quantisal? oral fluid device, stored cold and shipped overnight to the laboratory prior to testing. Blood specimens were collected simultaneously in gray top tubes. Results: From 23 pairs of samples, the median concentration in oral fluid was 524 μg/L and blood was 53 μg/L. The whole blood to plasma ratio for oxycodone was 1.3, so the median plasma concentration was 41 μg/L projecting a saliva to plasma ratio (S:P ratio) of 12. The comparison of oral fluid-blood concentrations allowed the projection of a S:P ratio for oxycodone and the development of a potential therapeutic range for oxycodone in oral fluid. Conclusion: Saliva drug concentrations in pain management are more closely related to blood levels than urine so can be more easily interpreted. These data provide a foundation for interpretative advances; however, further research surrounding other pain medications and controlled studies are necessary.
机译：目的：这项回顾性研究的目的是比较唾液和全血中羟考酮的浓度，以提出口服液中的治疗浓度。口服液是一种易于采集的标本，与尿液相比具有多种优势，包括易于采集和掺假困难。由于口服液是血液中循环的游离药物的反映，因此唾液中的药物浓度与血液水平的关系比尿液的浓度更为紧密。在过去几年中，提供分析尿液中止痛药的测试实验室的数量显着增加，同时止痛药（尤其是羟考酮）的使用和滥用也大大增加。因此，评估了口腔液分析在该领域的实用性。设计：回顾性研究成对的血液和口腔液标本，以建立反映治疗摄入量的羟考酮浓度范围。研究了二十三个成对的口腔液标本。口腔液样本已通过Quantisal？口服液设备，应冷藏保存，并在测试前通宵送到实验室。同时在灰色顶部试管中收集血液样本。结果：从23对样本中，口腔液中浓度为524μg/ L，血液中浓度为53μg/ L。羟考酮的全血与血浆之比为1.3，因此血浆中位数浓度为41μg/ L，唾液与血浆之比（S：P比）为12。比较口服液血浓度可以得出S ：羟考酮的：P比值和羟考酮在口服液中潜在治疗范围的发展。结论：疼痛控制中的唾液药物浓度与血液水平的关系比尿液更为密切，因此更容易解释。这些数据为解释性进展提供了基础。然而，围绕其他止痛药的进一步研究和对照研究是必要的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号