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首页> 外文期刊>Journal of ocular pharmacology and therapeutics: The official journal of the Association for Ocular Pharmacology and Therapeutics >Ocular hypotensive effects of anti-glaucoma agents in mice.
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Ocular hypotensive effects of anti-glaucoma agents in mice.

机译：抗青光眼剂对小鼠的降压作用。

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PURPOSE: To evaluate the ocular hypotensive effects induced by topical application of anti-glaucoma agents in mice. METHODS: Representative drugs (latanoprost and tafluprost [for prostanoid FP receptor agonists], timolol [for beta-adrenoceptor antagonists], dipivefrin [for alphabeta-adrenoceptor agonists], dorzolamide [for carbonic anhydrase inhibitors], pilocarpine [for muscarinic receptor agonists], bunazosin [for alpha(1)-adrenoceptor antagonists], or brimonidine [for alpha(2)-adrenoceptor agonists]) were used as anti-glaucoma agents; each one being topically applied once in a given male ddY mouse. Intraocular pressure (IOP) was measured using the microneedle method under general anesthesia. IOP was measured before, and at 1, 2, 3, and 4 h after administration of each drug. The contralateral eyes were untreated. At the each time point, the induced IOP reduction was evaluated by calculating the difference in IOP between the treated and untreated eyes in one and the same mouse. RESULTS: All of the evaluated anti-glaucoma agents reduced IOP in mice. The 2 prostanoid FP receptor agonists, the beta-adrenoceptor antagonist, and the alphabeta-adrenoceptor agonist began significantly to reduce IOP 2 h after their administration, and mostly induced a long-lasting IOP reduction. The alpha(1)-adrenoceptor antagonist, the alpha(2)-adrenoceptor agonist, the muscarinic receptor agonist, and the carbonic anhydrase inhibitor began reducing the IOP within 1 h after their administration, but their effects waned fairly quickly (the IOP reductions being lost by 3 h after their administration). Concomitant administration of timolol and tafluprost or of dorzolamide and tafluprost induced a significantly greater IOP reduction than that induced by either of the individual components. CONCLUSIONS: In this study, all the anti-glaucoma agents tested had apparent ocular hypotensive effects in mice. Our data suggest that the mouse may be a useful animal for the evaluation of the pharmacological effects of agents with various anti-glaucoma mechanisms, and for the evaluation of the enhanced ocular hypotensive effects that may be induced by the concomitant use of 2 anti-glaucoma agents.
机译：目的：评估局部应用抗青光眼剂在小鼠中引起的眼压降低作用。方法：代表性药物（拉坦前列素和他夫拉斯特[用于类前列腺素FP受体激动剂]，噻吗洛尔[用于β-肾上腺素受体拮抗剂]，双丙戊酸[用于字母-肾上腺素受体激动剂]，多佐胺[用于碳酸酐酶抑制剂]，毛果芸香碱[用于毒蕈碱受体激动剂]布尼唑嗪[用于α（1）-肾上腺素受体拮抗剂]或溴莫尼定[用于α（2）-肾上腺素受体激动剂]）被用作抗青光眼药。在给定的雄性ddY小鼠中，每只小鼠局部施用一次。在全身麻醉下使用微针法测量眼内压（IOP）。在服用每种药物之前和之后1、2、3和4小时测量IOP。对侧眼睛未经治疗。在每个时间点，通过计算一只和同一只小鼠中治疗和未治疗的眼睛之间的IOP差异来评估诱导的IOP降低。结果：所有评估的抗青光眼药物均能降低小鼠的眼压。 2种前列腺素FP受体激动剂，β肾上腺素受体拮抗剂和字母a肾上腺素受体激动剂在给药后2小时开始显着降低IOP，并且大多引起持久的IOP降低。施用后1小时内，α（1）-肾上腺素受体拮抗剂，α（2）-肾上腺素受体激动剂，毒蕈碱受体激动剂和碳酸酐酶抑制剂开始降低IOP，但它们的作用很快减弱（IOP降低为服药3小时后消失）。噻吗洛尔和他氟普罗斯特或多佐胺和他氟普罗斯特的同时给药引起的眼压降低明显大于任何一种单独成分引起的眼压降低。结论：在这项研究中，所有测试的抗青光眼药物均对小鼠具有明显的降眼压作用。我们的数据表明，小鼠可能是一种有用的动物，可用于评估具有多种抗青光眼机制的药物的药理作用，以及用于评估可能因同时使用2种抗青光眼而引起的眼压降低的作用代理商。

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