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A review of the predisposing, precipitating and perpetuating factors in Chronic Fatigue Syndrome in children and adolescents

机译:儿童和青少年慢性疲劳综合征的诱发因素,诱发因素和持久因素综述

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摘要

Chronic Fatigue Syndrome (CFS) is a condition characterised by severe mental and physical fatigue coupled with profound disability. The purpose of this review was to investigate psychological, social and physiological factors associated with fatigue and disability in CFS in children and adolescents. The review aimed to gain an overview of the strength of evidence for the relationship between these different factors and CFS in young people. Seventy-nine studies met the inclusion criteria and were included in the review. A narrative synthesis of these studies was conducted. The strongest and most consistent finding was that rates of psychiatric co-morbidity, predominantly anxiety and depressive disorders, were higher in young people with CFS compared to healthy controls or illness control groups. Studies suggested that many children and adolescents with CFS reported that their illness began with an infection and there was some objective and prospective evidence to support this. Preliminary evidence suggested a link between CFS and a family history of CFS, high expectations from both the parent and child, personality traits such as conscientiousness and physical illness attributions. The evidence was limited by methodological problems. Few studies were prospective in nature and future research should address this. Clinical implications of the findings are discussed and a hypothesised model of the factors associated with CFS in children and adolescents is presented.
机译:慢性疲劳综合症(CFS)是一种以严重的身心疲劳和严重残疾为特征的疾病。这篇综述的目的是调查与儿童和青少年CFS疲劳和残疾相关的心理,社会和生理因素。这篇综述旨在概述这些不同因素与年轻人CFS之间关系的证据强度。共有79项研究符合纳入标准,并被纳入评价。这些研究的叙述进行了综合。最强有力,最一致的发现是,与健康对照组或疾病对照组相比,患有CFS的年轻人的精神病合并症(主要是焦虑症和抑郁症)的发生率更高。研究表明,许多患有CFS的儿童和青少年报告说,他们的疾病始于感染,并且有一些客观和前瞻性的证据支持这一点。初步证据表明,CFS与CFS家族史之间存在联系,父母和孩子的期望很高,人格特征(如尽责和身体疾病的归因)。证据受到方法论问题的限制。很少有前瞻性的研究,未来的研究应该解决这个问题。讨论了该发现的临床意义,并提出了儿童和青少年与CFS相关因素的假设模型。

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