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首页> 外文期刊>CNS drug reviews >Pharmacological properties of BN82451: a novel multitargeting neuroprotective agent.
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Pharmacological properties of BN82451: a novel multitargeting neuroprotective agent.

机译：BN82451的药理特性：一种新型的多靶点神经保护剂。

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摘要

BN82451 belongs to a new family of small molecules designated as multitargeting or hybrid molecules. BN82451 is orally active, has good central nervous system penetration, and elicits potent neuronal protection and antiinflammatory properties. Neuronal protection is due to Na+ channel blockade, antioxidant properties, and mitochondria-protecting activity, whereas inhibition of cyclooxygenases is mostly responsible for its antiinflammatory activity. BN82451 has been shown to exert a potent neuroprotective effect in various in vitro and in vivo animal models. BN82451 was found to exert a significant protection in experimental animal models mimicking aspects of cerebral ischemia, Parkinson disease, Huntington disease, and more particularly amyotrophic lateral sclerosis. Collectively, its pharmacological properties designate BN82451 as a promising neuroprotective agent.
机译：BN82451属于新的小分子家族，被称为多靶分子或杂合分子。 BN82451具有口服活性，具有良好的中枢神经系统渗透能力，并具有强大的神经保护和抗炎特性。神经元保护作用归因于Na +通道阻滞，抗氧化特性和线粒体保护活性，而抑制环氧合酶主要是其抗炎活性。已显示BN82451在各种体外和体内动物模型中均发挥有效的神经保护作用。发现BN82451在模拟脑缺血，帕金森氏病，亨廷顿病，尤其是肌萎缩性侧索硬化的实验动物模型中发挥重要保护作用。总的来说，其药理特性将BN82451指定为有前途的神经保护剂。

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