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首页> 外文期刊>Journal of obstetrics and gynaecology: the journal of the Institute of Obstetrics and Gynaecology >Transforming growth factor beta(1) levels in platelet depleted plasma in African women with pre-eclampsia.
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Transforming growth factor beta(1) levels in platelet depleted plasma in African women with pre-eclampsia.

机译:患有先兆子痫的非洲女性血小板贫血血浆中转化生长因子β(1)的水平。

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摘要

Recently it has been suggested that TGF-beta(1) may play an important role in trophoblast invasion of spiral arteries in pre-eclampsia. This study was designed to investigate TGF-beta(1) levels in pre-eclampsia. Platelet depleted plasma TGF-beta(1) levels were measured by ELISA in 43 normotensive healthy non-pregnant women, 30 normotensive healthy pregnant and 42 pre-eclamptic women: TGF-beta(1) levels were increased significantly in the pre-eclamptics (4.9+/-0.9 ng/ml) compared to the normotensive pregnant (1.9+/-0.54 ng/ml; P<0.001) and normotensive non-pregnant groups (2.1+/-0.41 ng/ml; P<0.0001). There was no significant difference in TGF-beta(1) levels between normotensive pregnant and non-pregnant groups (1.9+/-0.54 vs. 2.1+/-0.41 ng/ml; P=0.2). There was a highly significant correlation between neonatal weight (r=0.63; P<0.0001) and TGF-beta(1) levels. The finding of increased levels of plasma TGF-beta(1) suggests an aetiological role of this peptide in pre-eclampsia.
机译:最近,有人提出,先兆子痫中TGF-beta(1)可能在滋养细胞侵袭螺旋动脉中起重要作用。这项研究旨在调查先兆子痫中的TGF-beta(1)水平。通过ELISA测定了43例血压正常健康的非孕妇,30例血压正常健康的孕妇和42例先兆子痫妇女的血小板消耗血浆TGF-beta(1)水平:先兆子痫患者中TGF-beta(1)的水平显着升高与血压正常的孕妇(1.9 +/- 0.54 ng / ml; P <0.001)和血压正常的非怀孕组(2.1 +/- 0.41 ng / ml; P <0.0001)相比,为4.9 +/- 0.9 ng / ml。在正常血压的孕妇和非孕妇组之间,TGF-β(1)水平没有显着差异(1.9 +/- 0.54 vs. 2.1 +/- 0.41 ng / ml; P = 0.2)。新生儿体重(r = 0.63; P <0.0001)与TGF-beta(1)水平之间存在高度显着的相关性。血浆TGF-β(1)水平升高的发现提示该肽在先兆子痫中的病因作用。

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