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首页> 外文期刊>Journal of occupational and environmental medicine >Systemic Inflammation Associated With World Trade Center Dust Exposures and Airway Abnormalities in the Local Community
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Systemic Inflammation Associated With World Trade Center Dust Exposures and Airway Abnormalities in the Local Community

机译：与世界贸易中心当地居民接触粉尘和呼吸道异常相关的系统性炎症

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Background: Destruction of the World Trade Center (WTC) towers on September 11, 2001, released massive dust, gas, and fumes with environmental exposures for community members. Many community members have lower respiratory symptoms (LRSs) that began after September 11, 2001, and remain persistent. We evaluated whether systemic inflammation measured by C-reactive protein was associated with WTC dust exposures, persistent LRS, and lung function. Methods: Community members self-referred for the treatment of symptoms related to September 11, 2001. C-reactive protein and lung function measurements, including spirometry and forced oscillation tests (impulse oscillometry system), were included as routine analyses in patients (2007 to 2012). Results: Increased C-reactive protein levels were associated with the type of WTC dust exposure, LRS, reduced spirometry, and increased forced oscillation measurements (n = 724). Conclusions: Ongoing systemic inflammation measured years after the event was associated with WTC dust exposures, persistent LRS, and abnormal lung function in a community cohort. These findings have implications for treatment and surveillance.
机译：背景：2001年9月11日，世界贸易中心（WTC）塔楼遭到破坏，向社区成员释放了大量粉尘，气体和烟雾，并暴露于环境中。许多社区成员的下呼吸道症状（LRS）始于2001年9月11日，并且一直持续存在。我们评估了通过C反应蛋白测得的全身性炎症是否与WTC尘埃暴露，持续性LRS和肺功能相关。方法：社区成员自荐用于治疗与2001年9月11日有关的症状。C反应蛋白和肺功能的测量，包括肺活量测定和强迫振荡试验（脉冲示波法），被纳入患者的常规分析（2007年至2007年）。 2012）。结果：C反应蛋白水平升高与WTC灰尘暴露类型，LRS，肺活量减少和强制振荡测量值增加相关（n = 724）。结论：事件后数年进行的持续性全身炎症与社区人群中的WTC尘埃暴露，持续的LRS和肺功能异常有关。这些发现对治疗和监测有影响。

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