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首页> 外文期刊>Journal of occupational and environmental medicine >Dose-response relationships between occupational aerosol exposures and cross-shift declines of lung function in poultry workers: recommendations for exposure limits.
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Dose-response relationships between occupational aerosol exposures and cross-shift declines of lung function in poultry workers: recommendations for exposure limits.

机译：家禽工人职业性气溶胶暴露与肺功能交叉转换下降之间的剂量反应关系：暴露极限建议。

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Numerous articles have been published regarding the adverse respiratory health consequences of working in intensive livestock and poultry housing. Threshold limit exposure guidelines are not currently applied to this environment, but they are essential to implement and monitor effective environmental controls. Previous dose-response research work with swine workers has resulted in exposure limit recommendations of 2.5 mg/m3 total dust, 0.23 mg/m3 respirable dust, 100 EU/m3 endotoxin, and 7 ppm ammonia. No similar recommendations have been reported previously for poultry workers. Therefore, an industry-wide study was conducted to examine dose-response relationships of bioaerosol exposures and worker respiratory health. A total of 257 poultry workers were studied for respiratory symptoms, pulmonary function, and exposure to dust (total and respirable), endotoxin (respirable and total), and ammonia. Details of the sampling plan and environmental assessment are described elsewhere. Relationships between exposures and response were studied by correlation and multiple regressions. Significant dose-response relationships were observed between exposures and pulmonary function decrements over a work shift. Exposure concentrations associated with significant pulmonary function decrements were as follows: 2.4 mg/m3 total dust, 0.16 mg/m3 respirable dust, 614 EU/m3 endotoxin, and 12 ppm ammonia.
机译：关于在密集的畜禽舍工作的不利呼吸健康后果，已经发表了许多文章。阈限值暴露准则目前尚未应用于此环境，但是它们对于实施和监视有效的环境控制至关重要。先前与养猪工人进行的剂量反应研究工作得出的暴露极限建议为：总粉尘2.5 mg / m3，可吸入粉尘0.23 mg / m3、100 EU / m3内毒素和7 ppm氨水。以前没有关于家禽工人的类似建议的报道。因此，进行了一项全行业研究，以检查生物气溶胶暴露与工人呼吸健康之间的剂量反应关系。总共对257名家禽工人进行了呼吸道症状，肺功能以及接触粉尘（全部和可呼吸），内毒素（可呼吸和全部）和氨的研究。采样计划和环境评估的详细信息将在其他地方介绍。通过相关和多元回归研究暴露与反应之间的关系。在工作班次中，暴露与肺功能下降之间存在显着的剂量反应关系。与肺功能显着降低相关的暴露浓度如下：总粉尘2.4 mg / m3，可吸入粉尘0.16 mg / m3、614 EU / m3内毒素和12 ppm氨。

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