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Etiology of sarcoidosis.

机译：结节病病因。

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Research over the past decade has advanced our understanding of the pathogenesis of sarcoidosis and provided new insights into potential causes of this disease. It is important to remember that any etiologic agent of sarcoidosis must be capable of causing the pathologic hallmark of systemic noncaseating granulomas and the heterogeneous clinical features of sarcoidosis. In addition, etiologic agents must be compatible with immunologic features, including polarized T-helper 1 cytokine profiles and oligoclonal T cell expansions consistent with antigen driven processes. Yet, even with studies conducted in this disease, there remains a lack of consensus on the etiology of sarcoidosis. This challenge is likely to be overcome only with additional research that incorporates clinical, genetic, immunologic, environmental, and microbiologic profiles in groups of patients, supplemented with testing of candidate pathogenic agents in experimental models that recapitulate critical features of this disease.
机译：过去十年的研究已经使我们对结节病的发病机理有了更深入的了解，并为结节病的潜在病因提供了新的见解。重要的是要记住，结节病的任何病因都必须能够引起全身性非干酪性肉芽肿的病理学标志和结节病的异质临床特征。此外，病原体必须与免疫学特征兼容，包括极化的T-helper 1细胞因子谱和与抗原驱动过程一致的寡克隆T细胞扩增。但是，即使对该疾病进行了研究，结节病的病因学仍缺乏共识。只有通过在患者组中纳入临床，遗传，免疫，环境和微生物学特征的补充研究，并在概括该疾病关键特征的实验模型中测试候选病原体，才能克服这一挑战。

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