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首页> 外文期刊>Clinics in dermatology >Do hormones influence melanoma? Facts and controversies.
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Do hormones influence melanoma? Facts and controversies.

机译:激素会影响黑色素瘤吗?事实与争议。

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The issue of whether hormones influence malignant melanoma (MM) has been controversial for many years. Although early case reports demonstrated a negative effect of hormones, recent evidence has not supported a potential role for hormones in MM. We address whether exogenous and endogenous hormones influence a woman's risk for MM or affect her prognosis if diagnosed with MM. Multiple epidemiologic studies show the use of oral contraceptives or hormone replacement therapy does not appear to increase a woman's risk for MM. Pregnancy does not appear to influence a woman's risk of MM, nor does pregnancy appear to affect prognosis in the woman diagnosed with MM. When counseling the woman who is diagnosed with MM during pregnancy or during the childbearing years, future use of oral contraceptives or hormone replacement therapy is not contraindicated; counseling concerning future pregnancies should be done on a case-by-case basis, with emphasis placed on established prognostic factors for MM.
机译:激素是否影响恶性黑色素瘤(MM)的问题已有多年争议。尽管早期病例报告显示激素具有负面作用,但最近的证据并未支持激素在MM中的潜在作用。我们探讨外源性激素和内源性激素是否会影响女性罹患MM的风险,或者是否会在诊断为MM时影响女性的预后。多项流行病学研究表明,口服避孕药或激素替代疗法似乎并未增加女性患MM的风险。怀孕似乎不会影响女性患MM的风险,怀孕似乎也不会影响诊断为MM的女性的预后。在怀孕或生育期间为被诊断患有MM的女性提供咨询时,不建议将来使用口服避孕药或激素替代疗法;有关未来怀孕的咨询应根据具体情况进行,重点放在确定的MM预后因素上。

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