The role of the gel double left right arrow liquid-crystalline phase transition in the lung surfactant cycle

Gugliotti M.; Politi MJ.

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The role of the gel double left right arrow liquid-crystalline phase transition in the lung surfactant cycle

机译：凝胶双向左向右箭头液晶相变在肺表面活性剂循环中的作用

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Lipid polymorphism plays an important role in the lung surfactant cycle. A better understanding of the influence of phase transitions on the formation of a lipid film from dispersions of vesicles will help to describe the mechanism of action of lung surfactant. The surface pressure (or tension) of dispersions of DPPC, DMPC, and DPPE unilamellar vesicles was studied as a function of temperature. These aggregates rapidly fuse with a clean air-water interface when the system is at their phase transition temperature (T-m), showing a direct correlation between phase transition and film formation. Based on these results, an explanation on how fluid aggregates in the alveolar subphase can form a rigid monolayer at the alveolar interface is proposed. (C) 2001 Elsevier Science B.V. All rights reserved. [References: 52]

机译：脂质多态性在肺表面活性剂循环中起重要作用。更好地理解相变对由囊泡分散形成脂质膜形成的影响，将有助于描述肺表面活性剂的作用机理。研究了DPPC，DMPC和DPPE单层囊泡分散液的表面压力（或张力）随温度的变化。当系统处于其相变温度（T-m）时，这些聚集体迅速与清洁的空气-水界面融合，显示出相变与成膜之间的直接关系。基于这些结果，提出了关于肺泡亚相中的流体聚集物如何在肺泡界面处形成刚性单层的解释。（C）2001 Elsevier Science B.V.保留所有权利。 [参考：52]

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《Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena》 |2001年第3期|共9页
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Gugliotti M.; Politi MJ.;
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正文语种 eng
中图分类生物化学;生物物理学;
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1. 双向凝胶电泳-飞行时间质谱法分析人肺鳞癌细胞NCI-H520蛋白质组成分 [J] . 詹显全, 陈主初, 关勇军, 癌症（英文版） . 2001,第006期
2. The role of the gel double left right arrow liquid-crystalline phase transition in the lung surfactant cycle [J] . Gugliotti M., Politi MJ. Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena . 2001,第2a3期

机译：凝胶双向左向右箭头液晶相变在肺表面活性剂循环中的作用
3. Winsor I double left right arrow III double left right arrow II microemulsion phase behavior of hydrofluoroethers and fluorocarbon/hydrocarbon catanionic surfactants [J] . Baran JR. Journal of Colloid and Interface Science . 2001,第1期

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5. Molecular Insights into the Gel to Liquid-Crystalline Phase Transition of Phospholipid Bilayers [C] . Lindong Weng, Gloria D. Elliott Society for Biomaterials annual meeting and exposition . 2015

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6. Molecular dynamics simulation of phase and structural transitions in model lung surfactant mixtures. [D] . Duncan, Susan L. 2010

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7. Permeability of dimyristoyl phosphatidylcholine/dipalmitoyl phosphatidylcholine bilayer membranes with coexisting gel and liquid-crystalline phases. [O] . S G Clerc, T E Thompson 1995

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8. Theory of Sol-Gel Transition in Thermoreversible Gels with due Regard for Fundamental Role of Mesoscopic Cyclization Effects. I. Thermodynamic and Structural Characteristics of Gel Phase [O] . Erukhimovich, Igor, Thamm, Michael V., Ermoshkin, Alexander V. 2001

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The role of the gel double left right arrow liquid-crystalline phase transition in the lung surfactant cycle

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