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首页> 外文期刊>Journal of molecular recognition: JMR >IgGs containing light chains of the lambda and kappa type and of all subclasses (IgG1-IgG4) from sera of patients with multiple sclerosis hydrolyze DNA.
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IgGs containing light chains of the lambda and kappa type and of all subclasses (IgG1-IgG4) from sera of patients with multiple sclerosis hydrolyze DNA.

机译：多发性硬化症患者血清中含有λ和κ型轻链以及所有亚类（IgG1-IgG4）轻链的IgG会水解DNA。

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摘要

We present the first evidence demonstrating that small fractions of IgGs of all four subclasses (IgG1-IgG4) are catalytically active in the hydrolysis of DNA and on average their relative activity (nM supercoiled DNA/1mg IgG/1 h) increases in the order: IgG1 (0.58) < IgG2 (0.94) < IgG3 (1.4) < IgG4 (4.1), while their approximate relative contribution to the total activity of abzymes increases in the order: IgG1 (6.9%) < IgG3 (9.3%) < IgG2 (18.2%) < IgG4 (65.6%). On average IgGs containing light chains of the lambda-type are severalfold more active in the hydrolysis of DNA than IgGs with light chains of the kappa-type. Using different physicochemical methods of antibody analysis we have shown that the immune system of multiple sclerosis patients generates a variety of anti-DNA abzymes of different type and with different catalytic properties, which can play an important role in multiple sclerosis pathogenesis.
机译：我们提供的第一个证据表明，所有四个亚类的小部分IgG（IgG1-IgG4）在DNA水解中都具有催化活性，平均而言，它们的相对活性（nM​​超螺旋DNA / 1mg IgG / 1 h）依次增加： IgG1（0.58）

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