...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >From bistability to oscillations in a model for the isocitrate dehydrogenase reaction
【24h】

From bistability to oscillations in a model for the isocitrate dehydrogenase reaction

机译：从双稳性到异柠檬酸脱氢酶反应模型的振荡

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Considered is a bienzymatic system consisting of isocitrate dehydrogenase (IDH, EC 1.1.1.42), which transforms NADP(+) into NADPH, and of diaphorase (DIA, EC 1.8.1.4), which catalyzes the reverse reaction. Experimental evidence as well as a theoretical model show the possibility of a coexistence between two stable steady stales in this reaction system. The phenomenon originates from the regulatory properties of IDH. We extend the analysis of a theoretical model proposed for the IDH-DIA bienzymatic system and investigate the occurrence of different modes of bistability, with or without hysteresis, i.e. in the presence of two or only one limit point bounding the domain of multiple steady states. The analysis indicates that the two types of bistability may sometimes be observed sequentially as a given control parameter is progressively increased. We further obtain conditions in which sustained oscillations develop in the model. These results establish the isocitrate dehydrogenase reaction coupled to diaphorase as a suitable candidate for further experimental and theoretical studies of bistability and oscillations in biochemical systems. (C) 1998 Elsevier Science B.V. All rights reserved. [References: 25]
机译：考虑的双酶系统由异柠檬酸脱氢酶（IDH，EC 1.1.1.42）（可将NADP（+）转化为NADPH）和心肌黄递酶（DIA，EC 1.8.1.4）（可催化逆反应）组成。实验证据和理论模型表明，在该反应系统中，两种稳定稳态之间可能并存。这种现象源于IDH的监管特性。我们扩展了针对IDH-DIA双酶系统提出的理论模型的分析，并研究了在有或没有滞后的情况下，即在存在两个或仅一个限制多个稳态域的极限点的情况下，双稳态的不同模式的发生。分析表明，随着给定控制参数的逐渐增加，有时可能会顺序观察到两种类型的双稳态。我们进一步获得模型中持续振荡发展的条件。这些结果建立了与心肌黄递酶偶联的异柠檬酸脱氢酶反应，作为进一步的生化系统中双稳态和振荡的实验和理论研究的合适候选者。 （C）1998 Elsevier Science B.V.保留所有权利。 [参考：25]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号