• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Molecular Neuroscience: MN >From Vasoactive Intestinal Peptide (VIP) Through Activity-Dependent Neuroprotective Protein (ADNP) to NAP: A View of Neuroprotection and Cell Division.
【24h】

From Vasoactive Intestinal Peptide (VIP) Through Activity-Dependent Neuroprotective Protein (ADNP) to NAP: A View of Neuroprotection and Cell Division.

机译：从血管活性肠肽（VIP）到依赖于活性的神经保护蛋白（ADNP）到NAP：神经保护和细胞分裂的观点。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Accelerated neuronal death brings about cognitive as well as motor and other dysfunctions. A major neuropeptide, vasoactive intestinal peptide (VIP), has been shown to be neuroprotective. However, VIP-based drug design is hampered by the instability of the peptide and its limited bioavailability. Two independent approaches were thus taken to exploit VIP as a lead drug candidate: (1) Potent neuroprotective lipophilic analogs of VIP were synthesized, e.g. [stearyl-norleucine-17] VIP (SNV); and (2) potent neuroprotective peptide derivatives were identified that mimic the activity of VIP-responsive neuroprotective glial proteins. VIP provides neuronal defense by inducing the synthesis and secretion of neuroprotective proteins from astrocytes; activitydependent neuroprotective protein (ADNP) was discovered as such glial cell mediator of VIP- and SNV-induced neuroprotection. In subsequent studies, an eight-amino-acid peptide, NAP, was identified as the smallest active element of ADNP exhibiting potent neuroprotective activities. This paper summarizes the biological effects of SNV and NAP and further reports advances in NAP studies toward clinical development. An original finding described here shows that NAP, while protecting neurons, demonstrated no apparent effect on cell division in a multiplicity of cell lines, strengthening the notion that NAP is a specific neuroprotective drug candidate.
机译：加速的神经元死亡导致认知以及运动和其他功能障碍。主要的神经肽，血管活性肠肽（VIP）已显示具有神经保护作用。但是，基于VIP的药物设计受到肽的不稳定性及其有限的生物利用度的阻碍。因此采取了两种独立的方法来将VIP用作主要药物候选药物：（1）合成了VIP的有效神经保护性亲脂性类似物，例如[stearyl-norleucine-17] VIP（SNV）; （2）鉴定出有效的神经保护肽衍生物，可模仿VIP反应神经保护神经胶质蛋白的活性。 VIP通过诱导星形胶质细胞合成和分泌神经保护蛋白来提供神经防御作用。发现了依赖活性的神经保护蛋白（ADNP）作为这种由VIP和SNV诱导的神经保护的神经胶质细胞介体。在随后的研究中，八氨基酸肽NAP被确定为ADNP的最小活性元素，具有强大的神经保护活性。本文总结了SNV和NAP的生物学效应，并进一步报道了NAP研究在临床开发方面的进展。此处描述的原始发现表明，NAP在保护神经元的同时，并未显示出对多种细胞系中细胞分裂的明显影响，从而强化了NAP是特定的神经保护药物候选物的观念。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号