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首页> 外文期刊>CNS drug reviews >The Neuropsychopharmacology and Toxicology of 3,4-methylenedioxy-N-ethyl-amphetamine (MDEA).
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The Neuropsychopharmacology and Toxicology of 3,4-methylenedioxy-N-ethyl-amphetamine (MDEA).

机译：3,4-亚甲二氧基-N-乙基苯丙胺（MDEA）的神经心理药理和毒理学。

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This paper reviews the pharmacology and toxicology of 3,4-methylenedioxy-N-ethylamphetamine (MDEA, "eve"). MDEA is a ring-substituted amphetamine (RSA) like MDMA, its well known N-methyl analog. Both have become very popular substances of abuse in the techno- and house-music scene. They can evoke psychomotor stimulation, mild alterations of perception, sensations of closeness and a positive emotional state as well as sympathomimetic physical effects. At present, the name "ecstasy" is no longer used only for MDMA, but for the whole group of RSAs (MDA, MDMA, MDEA and MBDB) as they are chemically and pharmacologically nearly identical; moreover, many ecstasy pills contain mixtures of the RSAs. Hence, for a selective review on MDEA, it is crucial to strictly differentiate between: 1) street and chemical names, and 2) studies with or without chemically defined substances. In order to present MDEA-specific information, the pharmacodynamics and kinetics are described on the basis of MDEA challenge studies in animals and humans. In the toxicology section, we present a collection of case reports on fatalities where MDEA was toxicologically confirmed. On the question of serotonergic neurotoxicity and possible long-term consequences, however, MDEA-specific information is available from animal studies only. The neurotoxic potential of MDEA in humans is difficult to estimate, as ecstasy users do not consume pure substances. For future research, challenge studies in animals using dosing regimens adapted to human consumption patterns are needed. Such challenge studies should directly compare individual RSAs. They will represent the most viable and fruitful approach to the resolution of the highly controversial issues of serotonergic neurotoxicity and its functional consequences.
机译：本文综述了3,4-亚甲二氧基-N-乙基苯丙胺（MDEA，“ eve”）的药理和毒理作用。 MDEA是一种环取代的苯丙胺（RSA），如MDMA（众所周知的N-甲基类似物）。在技​​术和家庭音乐领域，两者都已成为非常普遍的滥用行为。它们可以引起精神运动刺激，知觉的轻度改变，亲密感和积极的情绪状态以及拟交感神经的物理作用。目前，“摇头丸”的名称不再仅仅用于MDMA，而是用于整个RSA（MDA，MDMA，MDEA和MBDB），因为它们在化学和药理上几乎是相同的。此外，许多摇头丸包含RSA的混合物。因此，对于MDEA的选择性审查，严格区分以下内容至关重要：1）街道名称和化学名称，以及2）使用或不使用化学定义的物质进行的研究。为了提供MDEA特有的信息，在对MDEA进行的动物和人类攻击研究的基础上描述了药效学和动力学。在毒理学部分，我们提供了有关通过毒理学证实的MDEA死亡的病例报告的集合。然而，关于血清素神经毒性和可能的​​长期后果的问题，MDEA特有的信息只能从动物研究中获得。由于摇头丸使用者不消耗纯净物质，因此难以估计MDEA对人的神经毒性。对于未来的研究，需要使用适合人类消费方式的给药方案对动物进行挑战研究。此类挑战研究应直接比较各个RSA。它们将代表解决血清素能神经毒性及其功能后果这一极富争议的问题的最可行，最富有成果的方法。

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