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首页> 外文期刊>CNS drug reviews >Therapeutic potential of wogonin: a naturally occurring flavonoid.
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Therapeutic potential of wogonin: a naturally occurring flavonoid.

机译：wogonin的治疗潜力：一种天然存在的类黄酮。

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摘要

The search for flavonoids with novel therapeutic effects has been intense. Wogonin, as a naturally existing monoflavonoid, has been shown to have therapeutic potential in vitro and in vivo. Methods for its extraction from herbs and its chemical synthesis have been developed. Pharmacokinetic studies have shown a rapid tissue distribution and prolonged plasma elimination phase of wogonin. It has been shown experimentally that wogonin exerts anti-oxidant activity, which may, in part, underlie its antiinflammatory, anti-cancer, antiviral and neuroprotective actions. The recent discovery of its anxiolytic activity suggests a new mechanism of action, involving interaction with the benzodiazepine (BZD) binding site of the GABA(A) receptor and modulation of this receptor activity. Although the safety record of wogonin is remarkable and voluminous literature about its pharmacological effects is available, it has not been used in Western medicine in the form of a pure chemical. In this article we review its therapeutic effects, its sources and pharmacokinetic profile to highlight its therapeutic potential.
机译：对具有新颖治疗作用的类黄酮的研究一直很激烈。 Wogonin作为天然存在的单黄酮类化合物，已显示出在体内和体外具有治疗潜力。已经开发了从草药中提取和化学合成的方法。药代动力学研究表明，wogonin具有快速的组织分布和延长的血浆消除期。实验表明，沃戈宁具有抗氧化活性，这可能部分是其抗炎，抗癌，抗病毒和神经保护作用的基础。其抗焦虑活性的最新发现表明了一种新的作用机理，涉及与GABA（A）受体的苯并二氮杂（BZD）结合位点相互作用以及对该受体活性的调节。尽管沃戈宁的安全性记录非常出色，并且已有大量有关其药理作用的文献，但尚未以纯化学药品的形式用于西药。在本文中，我们回顾了其治疗效果，其来源和药代动力学概况，以突出其治疗潜力。

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