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首页> 外文期刊>Journal of paediatrics and child health >Comparison of stool microbiota compositions, stool alpha1-antitrypsin and calprotectin concentrations, and diarrhoeal morbidity of Indonesian infants fed breast milk or probiotic/prebiotic-supplemented formula
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Comparison of stool microbiota compositions, stool alpha1-antitrypsin and calprotectin concentrations, and diarrhoeal morbidity of Indonesian infants fed breast milk or probiotic/prebiotic-supplemented formula

机译：喂养母乳或补充益生菌/益生元的印度尼西亚婴儿的粪便微生物群组成，粪便α1-抗胰蛋白酶和钙卫蛋白浓度以及腹泻发病率的比较

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Aim The composition of faecal microbiota of babies is known to be influenced by diet. Faecal calprotectin and α1-antitrypsin concentrations may be associated with mucosal permeability and inflammation. We aimed to assess whether there was any difference after consumption of a probiotic/prebiotic formula on faecal microbiota composition, calprotectin and α1-antitrypsin levels, and diarrhoea in comparison with breast milk-fed Indonesian infants. Methods One hundred sixty infants, 2 to 6 weeks old, were recruited to the study. They were either breastfed or formula fed (80 per group). Faecal samples were collected at recruitment and 3 months later. Bacterial groups characteristic of the human faecal microbiota were quantified in faeces by quantitative polymerase chain reaction. Calprotectin and α1-antitrypsin concentrations were measured using commercial kits. Details of diarrhoeal morbidity were documented and rated for severity. Results The compositions of the faecal microbiota of formula-fed compared with breast milk-fed children were similar except that the probiotic strain Bifidobacterium animalis subsp. lactisa?...DR10 was more abundant after 3 months consumption of the formula. Alpha1-antitrypsin levels were higher in breastfed compared with formula-fed infants. The occurrence of diarrhoea did not differ between the groups of babies. Conclusion Feeding Indonesian babies with a probiotic/prebiotic formula did not produce marked differences in the composition of the faecal microbiota in comparison with breast milk. Detrimental effects of formula feeding on biomarkers of mucosal health were not observed.
机译：目的已知婴儿的粪便微生物群的组成会受到饮食的影响。粪便钙卫蛋白和α1-抗胰蛋白酶的浓度可能与粘膜通透性和炎症有关。我们旨在评估与母乳喂养的印度尼西亚婴儿相比，食用益生菌/益生元配方后的粪便微生物群组成，钙卫蛋白和α1-抗胰蛋白酶水平以及腹泻是否存在任何差异。方法招募2至6周大的婴儿160例。他们采用母乳喂养或配方奶喂养（每组80只）。在募集时和3个月后收集粪便样品。通过定量聚合酶链反应在粪便中定量人类粪便微生物群的细菌群特征。使用商业试剂盒测量钙卫蛋白和α1-抗胰蛋白酶的浓度。腹泻病的详细情况已记录在案，并进行了严重程度评定。结果配方奶喂养的粪便微生物菌群与母乳喂养的儿童相比相似，只是益生菌菌株动物双歧杆菌亚种。食用该配方奶3个月后，lactisa？... DR10含量更高。与配方食品喂养的婴儿相比，母乳喂养的α1-抗胰蛋白酶水平更高。婴儿组之间的腹泻发生率没有差异。结论用益生菌/益生元配方奶喂养印尼婴儿与母乳相比，粪便微生物群的组成没有明显差异。没有观察到配方奶喂养对粘膜健康生物标志物的有害影响。

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