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首页> 外文期刊>Journal of paediatrics and child health >Feasibility of trialling cord blood stem cell treatments for cerebral palsy in Australia
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Feasibility of trialling cord blood stem cell treatments for cerebral palsy in Australia

机译：在澳大利亚试验性脐带血干细胞治疗脑瘫的可行性

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Aim Umbilical cord blood may have therapeutic benefit in children with cerebral palsy (CP), but further studies are required. On first appearance it seems that Australia is well placed for such a trial because we have excellence in CP research backed by extensive CP registers, and both public and private cord blood banks. We aimed to examine the possibilities of conducting a trial of autologous umbilical cord blood cells (UCBCs) as a treatment for children with CP in Australia. Methods Data linkages between CP registers and cord blood banks were used to estimate potential participant numbers for a trial of autologous UCBCs for children with CP. Results As of early 2013, one Victorian child with CP had cord blood stored in the public bank, and between 1 and 3 children had their cord blood stored at Cell Care Australia (private cord blood bank). In New South Wales, we counted two children on the CP register who had their stored cord blood available in early 2013. We estimate that there are between 10 and 24 children with CP of any type who have autologous cord blood available across Australia. Conclusions In nations with small populations like Australia, combined with Australia's relatively low per capita cord blood storage to date, it is not currently feasible to conduct trials of autologous UCBCs for children with CP. Other options must be explored, such as allogeneic UCBCs or prospective trials for neonates at risk of CP.
机译：目的脐带血可能对患有脑瘫（CP）的儿童有治疗作用，但需要进一步的研究。乍看起来，澳大利亚似乎很适合进行此类试验，因为我们在CP研究方面拥有卓越的经验，并拥有大量CP注册者以及公共和私人脐带血库的支持。我们旨在研究在澳大利亚进行自体脐带血细胞（UCBC）试验以治疗患有CP的儿童的可能性。方法使用CP寄存器和脐带血库之间的数据链接来估计潜在的参与者人数，以进行CP儿童的自体UCBC试验。结果截至2013年初，一名维多利亚州CP患儿的脐带血已保存在公共银行中，而1至3名儿童的脐带血已保存在澳大利亚Cell Care（私人脐血库）中。在新南威尔士州，我们计算了CP登记册上的两个孩子，这些孩子在2013年初有可用的脐带血。我们估计，澳大利亚有10至24名患有任何类型CP的儿童都有自体脐带血。结论在澳大利亚等人口少的国家，再加上迄今为止澳大利亚人均脐带血的储量相对较低，目前尚不可行对患有CP的儿童进行自体UCBC的试验。必须探索其他选择，例如同种异体UCBC或对有CP风险的新生儿进行前瞻性试验。

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