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首页> 外文期刊>Journal of paediatrics and child health >Vitamin D insufficiency among hospitalised children in the Northern Territory
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Vitamin D insufficiency among hospitalised children in the Northern Territory

机译：北部地区住院儿童的维生素D功能不足

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Aim Acute lower respiratory infections (ALRIs) are the most common reason for hospitalisation of young children in the Northern Territory of Australia. International studies have linked vitamin D deficiency with increased risk of ALRI in paediatric populations, but this has not been explored in tropical regions such as the Top End of the Northern Territory. The aim of this study is to determine the prevalence of vitamin D insufficiency among children hospitalised with ALRI in the Northern Territory. Methods Vitamin D serum metabolite (25OHD3) levels were retrospectively measured using liquid chromatography-mass spectrometry in 74 children (64% male; 57% Indigenous) aged less than 3 years admitted to Royal Darwin Hospital in the Northern Territory of Australia between May 2008 and May 2010. Results There were 44 (59%) ALRI-classified hospitalisations and 30 (41%) non-ALRI-classified hospitalisations. The most common ALRI diagnoses were bronchiolitis (n = 22, 30%) and pneumonia (n = 21, 28%), whereas the most common non-ALRI diagnosis was gastroenteritis (n = 20, 27%). Overall, 24/74 (32%) children had 25OHD3 levels <75 nmol/L (insufficiency). For children hospitalised with ALRI, 23% (10/44) had vitamin D insufficiency compared with 47% (14/30) among children hospitalised for other reasons (odds ratio 0.34, 95% confidence interval 0.11-1.03; P = 0.043). Twelve of the 20 (60%) children hospitalised for gastroenteritis had vitamin D insufficiency. Conclusions Vitamin D insufficiency was observed in almost one-third of these hospitalised children. Children hospitalised with an ALRI were less likely to have vitamin D insufficiency compared with children hospitalised for other conditions (predominantly gastroenteritis).
机译：目的急性下呼吸道感染（ALRIs）是澳大利亚北领地幼儿住院的最常见原因。国际研究已将维生素D缺乏与儿童人群中ALRI的风险增加联系起来，但是在热带地区（如北领地的顶端）尚未对此进行研究。这项研究的目的是确定北领地ALRI住院的儿童中维生素D功能不足的患病率。方法采用液相色谱-质谱法对澳大利亚北领地皇家达尔文医院（Royal Darwin Hospital）于2008年5月至2008年5月至2006年3月入院的74名年龄在3岁以下的儿童（64％男性; 57％土著）中的维生素D血清代谢产物（25OHD3）水平进行了回顾性测量。 2010年5月。结果有44例（59％）ALRI分类住院和30例（41％）非ALRI分类住院。最常见的ALRI诊断为细支气管炎（n = 22，30％）和肺炎（n = 21，28％），而最常见的非ALRI诊断为肠胃炎（n = 20，27％）。总体而言，有24/74（32％）儿童的25OHD3水平<75 nmol / L（不足）。对于因ALRI住院的儿童，维生素D功能不足的比例为23％（10/44），而因其他原因住院的儿童中维生素D的比例为47％（14/30）（赔率0.34，95％置信区间0.11-1.03; P = 0.043）。在因胃肠炎住院的20名儿童中，有十二名（60％）患有维生素D功能不足。结论在这些住院的儿童中，近三分之一患有维生素D功能不足。与因其他疾病（主要是肠胃炎）住院的儿童相比，接受ALRI住院的儿童维生素D功能不足的可能性较小。

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