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首页> 外文期刊>Journal of paediatrics and child health >Are vitamin D levels affected by acute bacterial infections in children?
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Are vitamin D levels affected by acute bacterial infections in children?

机译：儿童的急性细菌感染会影响维生素D水平吗？

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Aims: Vitamin D deficiency is associated with infectious diseases; however, it is not known whether vitamin D levels are affected by acute infection. Our aim was to establish whether 25-hydroxyvitamin D (25OHD) levels taken during an acute bacterial infection are representative of baseline levels. Methods: Thirty children between 6 months and 15 years of age with proven bacterial infections presenting to a tertiary paediatric referral centre had 25OHD levels taken during their acute infection and again 1 month later provided that they had recovered from their infection, had no subsequent infections and had not been taking vitamin supplements. 25OHD levels were measured by liquid chromatography mass spectrometry. Results: Mean 25OHD at enrolment was 67.5 nmol/L (standard deviation (SD) 22.0), and mean 25OHD at 1 month follow up was 72.7 nmol/L (SD 25.8) (paired t-test P = 0.25). C-reactive protein levels were recorded in 29/30 patients at enrolment (mean 85.1 mg/L, SD 83.5) and 25/30 patients at follow-up (mean 4.0 mg/L, SD 3.3) (paired t-test P = 0.002). The ethnicity of the participants was New Zealand European or European Other, 26; Samoan, 2; Maori, 1; and Chinese, 1. Conclusions: In children, 25OHD levels are not affected by acute bacterial infections; 25OHD levels taken during acute bacterial infection are representative of baseline levels. 25OHD levels collected during acute bacterial infection provide reliable information for case-control studies.
机译：目的：维生素D缺乏症与传染病有关;但是，尚不知道维生素D水平是否会受到急性感染的影响。我们的目的是确定急性细菌感染期间服用的25-羟基维生素D（25OHD）水平是否代表基线水平。方法：30名年龄在6个月至15岁之间的儿童经三级儿科转诊中心确诊细菌感染后，在急性感染期间接受了25OHD的检测，并在1个月后再次接受检测，前提是他们已从感染中恢复过来，没有随后的感染，并且没有服用维生素补充剂。通过液相色谱质谱法测量25OHD水平。结果：入组时的平均25OHD为67.5 nmol / L（标准差（SD）22.0），随访1个月时的平均25OHD为72.7 nmol / L（SD 25.8）（配对t检验P = 0.25）。入组时29/30例患者记录了C反应蛋白水平（平均85.1 mg / L，SD 83.5），随访时记录了25/30例患者的C反应蛋白水平（平均4.0 mg / L，SD 3.3）（配对t检验P = 0.002）。参加者的种族为新西兰欧洲人或欧洲其他人26岁;萨摩亚2岁;毛利人1岁;结论：儿童的25OHD水平不受急性细菌感染的影响。急性细菌感染过程中采取的25OHD水平代表基线水平。急性细菌感染期间收集的25OHD水平为病例对照研究提供了可靠的信息。

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