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首页> 外文期刊>Journal of paediatrics and child health >Fluid resuscitation therapy for paediatric sepsis
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Fluid resuscitation therapy for paediatric sepsis

机译：液体复苏治疗小儿败血症

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摘要

Sepsis and septic shock are the final common pathway for many decompensated paediatric infections. Fluid resuscitation therapy has been the cornerstone of haemodynamic resuscitation in these children. Good evidence for equivalence between 0.9% saline and 4% albumin, with the relative expense of the latter, has meant that 0.9% saline is currently the most commonly used resuscitation fluid world-wide. Evidence for harm from the chloride load in 0.9% saline has generated interest in balanced solutions as first line resuscitation fluids. Their safety has been well established in observational studies, and they may well be the most reasonable default fluid for resuscitation. Semi-synthetic colloids have been associated with renal dysfunction and death and should be avoided. There is evidence for harm from excessive administration of any resuscitation fluid. Resuscitation fluid volumes should be treated in the same way as the dose of any other intravenously administered medication, and the potential benefits versus harms for the individual patient weighed prior to administration.
机译：败血症和败血性休克是许多失代偿儿科感染的最终通用途径。液体复苏疗法已成为这些儿童血液动力学复苏的基石。有充分的证据证明0.9％的生理盐水和4％的白蛋白相当，而后者的相对费用则意味着0.9％的生理盐水是目前全球范围内最常用的复苏液。有证据表明在0.9％的盐水中氯化物负载会造成伤害，因此人们对平衡溶液作为一线复苏液产生了兴趣。在观察研究中已经确定了它们的安全性，它们很可能是复苏时最合理的默认补液。半合成胶体与肾功能不全和死亡有关，应避免使用。有证据表明过度使用任何复苏液会造成伤害。复苏液的体积应与任何其他静脉内给药的药物剂量相同，并且在给药前应权衡患者的潜在获益与危害。

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