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首页> 外文期刊>Journal of pain and symptom management. >Rapid progression of advanced 'hormone-resistant' prostate cancer during palliative treatment with progestins for cancer cachexia.
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Rapid progression of advanced 'hormone-resistant' prostate cancer during palliative treatment with progestins for cancer cachexia.

机译：在用孕激素进行姑息治疗以缓解恶病质时，晚期“激素抵抗性”前列腺癌会迅速发展。

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摘要

We report three patients with advanced "hormone-resistant" prostate cancer, each of whom had rapid progression of the disease during treatment with megestrol acetate for cancer cachexia. All patients had been previously treated with total androgenic deprivation. With progression of the disease, megestrol acetate was given to palliate the cancer-related wasting syndrome. No other antineoplastic drugs were contemporaneously given, and no concomitant condition that could favor the progression of the disease was present. The worsening observed while receiving megestrol acetate, and the atypical withdrawal syndrome occurring after the treatment was stopped, seem to suggest a promoting role of megestrol acetate in advanced "hormone-resistant" prostate cancer. The risk of rapid disease progression overwhelming the anti-cachectic palliative effect should be kept in mind when progestins are administered as a palliative treatment of cancer cachexia in patients with advanced "hormone-resistant" prostate cancer.
机译：我们报告了三名患有晚期“激素抵抗”前列腺癌的患者，每位患者在用乙酸孕甾酮治疗癌症恶病质期间疾病进展迅速。所有患者先前均接受了完全雄激素剥夺治疗。随着疾病的发展，醋酸孕甾酮被用于缓解癌症相关的消耗综合征。没有同时使用其他抗肿瘤药，也没有伴随疾病发展的疾病出现。接受醋酸孕甾酮时观察到的病情恶化，以及停止治疗后发生的非典型戒断综合征，似乎表明醋酸孕甾酮在晚期“激素抵抗”前列腺癌中具有促进作用。当将孕激素作为晚期“激素抵抗”前列腺癌患者的恶病质的姑息治疗药物时，应牢记疾病快速发展使抗恶病质姑息作用不堪重负的风险。

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