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首页> 外文期刊>Journal of Oral and Maxillofacial Surgery >Changes in parathyroid hormone-related protein and 3-dimensional trabecular bone structure of the mandibular condyle following mandibular distraction osteogenesis in growing rats.
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Changes in parathyroid hormone-related protein and 3-dimensional trabecular bone structure of the mandibular condyle following mandibular distraction osteogenesis in growing rats.

机译：下颌骨牵引成骨后成年大鼠下颌骨con甲状旁腺相关蛋白和3维小梁骨结构的变化。

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PURPOSE: Distraction osteogenesis (DO) is commonly performed for mandibular reconstruction during the growth period. We tested the hypothesis that parathyroid hormone-related protein (PTHrP) in mandibular condylar cartilage and underlying trabecular bone in growing individuals undergo changes in response to distraction forces. MATERIALS AND METHODS: Forty-eight 6-week-old male Sprague-Dawley rats were used. Animals underwent unilateral mandibular distraction using a distractor that we devised, and unoperated animals were evaluated as controls. DO procedure was performed: 3 days' latency period, 0.4 mm/day rate, total 4.0 mm. Changes in cartilage morphology, PTHrP activity, and 3-dimensional trabecular bone structure changes measured by micro-computed tomography were examined at 0, 2, 4, and 6 weeks of consolidation. RESULTS: A marked irregularity was noted in the superior portion of the distracted side's condylar cartilage that resolved after distraction ceased. PTHrP was more strongly expressed in thehypertrophic layer of condylar cartilage on the distracted side than in controls, up to 6 weeks after the end of distraction. Subchondral trabecular bone volume, percent bone volume, and trabecular number in the superior and posterior regions of the condyle decreased significantly by 2 weeks after distraction. These parameters returned to normal in the posterior condyle, but not in the superior part of the condyle by 6 weeks following distraction. CONCLUSION: These results suggest that unilateral mandibular distraction in growing rats causes temporary morphologic alterations of trabecular bone structure on the distracted side accompanied by increased production of PTHrP in the mandibular condyle.
机译：目的：在成长期下颌骨重建中通常进行牵引成骨（DO）。我们测试了以下假说，即成年个体下颌dy突软骨和下层小梁骨中的甲状旁腺激素相关蛋白（PTHrP）会因分心力而发生变化。材料与方法：使用48只6周龄的雄性Sprague-Dawley大鼠。使用我们设计的牵引器对动物进行单侧下颌牵引，并将未手术的动物作为对照。进行DO程序：3天的潜伏期，0.4毫米/天的速率，总计4.0毫米。在巩固的0、2、4和6周时检查通过微计算机断层扫描测量的软骨形态，PTHrP活性和3维小梁骨结构变化。结果：在分心的一侧con突软骨的上半部发现了明显的不规则现象，该异常在分心停止后消失。 PTHrP在分心结束后长达6周时，在分心侧的con突软骨肥厚层中的表达高于对照组。牵引后2周，the上，后区的软骨下小梁骨体积，骨体积百分比和小梁数目明显减少。这些参数在dis后6周后恢复到正常，但在but后部则未恢复。结论：这些结果表明，成年大鼠的单侧下颌骨牵张会引起牵张侧小梁骨结构的暂时形态学改变，并伴随下颌con突中PTHrP产生的增加。

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