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首页> 外文期刊>Clinics in dermatology >Treatment of nonhealing ulcers with allografts.
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Treatment of nonhealing ulcers with allografts.

机译：同种异体移植治疗不愈的溃疡。

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摘要

Chronic wounds often represent a significant medical and economic challenge. Clinicians seek novel therapies poised to foster production of granulation tissue and subsequent healing. Cadaveric allograft remains the mainstay in burn therapy. Research, however, shows that this treatment functions adjunctively in complex nonhealing wounds by manipulating the microenvironment, preventing desiccation of underlying bone and tendon, augmenting wound-bed preparation, and producing rapid closure. The following review presents the rationale for incorporating skin allografts into the wound healing algorithm, including chronic wound biochemistry, wound-bed preparation, current applications, combination therapies, cost considerations, and case studies. Diagnosis and treatment of underlying etiologies remains essential. A multidisciplinary approach using accepted treatment protocols helps reduce morbidity and expense associated with these lesions.
机译：慢性伤口通常代表重大的医学和经济挑战。临床医生寻求新的疗法来促进肉芽组织的产生和随后的康复。尸体同种异体移植仍然是烧伤治疗的主要手段。然而，研究表明，这种处理可通过操纵微环境，防止下面的骨骼和肌腱干燥，增加伤口床准备并快速闭合来在复杂的不愈合伤口中辅助发挥作用。以下评论介绍了将皮肤同种异体移植物纳入伤口愈合算法的原理，包括慢性伤口生物化学，创面床准备，当前应用，联合疗法，成本考虑因素和案例研究。潜在病因的诊断和治疗仍然至关重要。使用公认的治疗方案的多学科方法有助于减少这些病变的发病率和费用。

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