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首页> 外文期刊>Journal of neurology >Thalamic interictal epileptiform discharges in deep brain stimulated epilepsy patients
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Thalamic interictal epileptiform discharges in deep brain stimulated epilepsy patients

机译：大脑深部刺激的癫痫患者丘脑发作癫痫样放电

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摘要

The relationships between interictal epileptiform discharges (IEDs) in the anterior (ANT) and dorsomedial nuclei (DMNT) of the thalamus and electro-clinical parameters in pharmacoresistant focal epilepsy patients receiving intrathalamic electrodes for deep brain stimulation (DBS) were investigated. Thalamus-localized IEDs (LIEDs) and surface EEG (sEEG)-IEDs were evaluated in eight patients who underwent ANT-DBS. Occurrence and frequency of ANT- and DMNT-LIEDs and pre-operative sEEG-IEDs were examined with respect to seizure onset location and seizure outcome following ANT-DBS. LIEDs were identified in all eight patients, in the ANT, DMNT, or both. ANT-LIEDs were observed in all patients with an unequivocal temporal seizure onset zone. The ANT-LIED frequency correlated with pre-surgical sEEG-IED frequency (rho = 0.76, p = 0.033) and predicted ANT-DBS responsiveness (T = -2.6; p = 0.0428). Of the five patients with bilateral sEEG-IEDs, all had ANT-LIEDs, but only one patient had DMNT-LIEDs. All patients with no or unilateral sEEG-IEDs had DMNT-LIEDs. Observation of LIEDS in the ANT and DMNT supports the hypothesis that these nuclei are involved in propagation of focal epileptic activity. Their correspondence with differing electro-clinical features suggests that these nuclei are functionally distinguishable nodes within the epileptic networks of individual patients.
机译：研究了接受丘脑内电极进行深部脑刺激（DBS）的耐药性局灶性癫痫患者的丘脑前部（ANT）和丘脑背核（DMNT）的发作性癫痫样放电（IED）与电临床参数之间的关系。在八名接受ANT-DBS的患者中评估了丘脑定位的IED（LIED）和表面EEG（sEEG）-IED。就ANT-DBS发作的发作位置和发作结果检查了ANT-和DMNT-LIED和术前sEEG-IED的发生和频率。在ANT，DMNT或两者中所有八名患者中均鉴定出LIED。在所有具有明确的颞癫痫发作区的患者中均观察到了ANT-LIEDs。 ANT-LIED频率与术前sEEG-IED频率相关（rho = 0.76，p = 0.033）和预测的ANT-DBS反应性（T = -2.6; p = 0.0428）。在5例双侧sEEG-IED患者中，所有患者均患有ANT-LIED，但只有1例患者患有DMNT-LIED。所有没有或没有单侧sEEG-IED的患者均患有DMNT-LIED。在ANT和DMNT中对LIEDS的观察支持了以下假设：这些核与局灶性癫痫活动的传播有关。它们与不同的电子临床特征的对应关系表明，这些核是单个患者癫痫网络中功能上可区分的节点。

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