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首页> 外文期刊>Journal of neurology >Cycle ergometry is not a sensitive diagnostic test for mitochondrial myopathy.
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Cycle ergometry is not a sensitive diagnostic test for mitochondrial myopathy.

机译：自行车测功不是针对线粒体肌病的敏感诊断测试。

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Cycle exercise has repeatedly been used to diagnose patients suspected of having mitochondrial myopathy (MM), in whom exercise intolerance and lactic acidosis are common. No standardized test, however, has been established. We evaluated the diagnostic value of incremental and constant workload (20 min at 65 % VO(2max)) cycle tests for the diagnosis of MM. Plasma lactate and oxidative capacity (VO(2) and workload) were measured in 15 well-characterized MM patients during cycling. Findings were compared with those in 10 myotonic dystrophy patients and 18 sedentary, healthy subjects.All MM patients had ragged red or COX-negative fibers on muscle biopsy. VO(2max) and maximal workload were lower in MM than in control groups (P < 0.02). Resting plasma lactate was higher in MM than in control groups (P < 0.005; sensitivity = 93 %; specificity = 85 %), while exercise-induced increases in plasma lactate were only higher during the constant workload protocol in MM patients vs. control groups (P < 0.05; sensitivity = 27 %; specificity = 86 %). The findings indicate that the diagnostic value of a constant workload protocol is superior to an incremental cycle test, but that the test is less sensitive for MM than simple testing of resting lactate and muscle morphology. Cycle testing of MM patients remains an important research tool, but should not be a standard diagnostic procedure for MM.
机译：循环运动已被反复用于诊断怀疑患有线粒体肌病（MM）的患者，其中运动不耐症和乳酸性酸中毒很常见。但是，尚未建立标准化测试。我们评估了增量和恒定工作量（65％VO（2max）下20分钟）对MM诊断的诊断价值。在15名特征明确的MM患者骑车期间测量了血浆乳酸和氧化能力（VO（2）和工作量）。将结果与10例强直性肌营养不良患者和18例久坐的健康受试者的结果进行了比较。所有MM患者的肌肉活检均具有参差不齐的红色或COX阴性纤维。 MM的VO（2max）和最大工作量低于对照组（P <0.02）。 MM患者的静息血浆乳酸水平高于对照组（P <0.005;敏感性= 93％;特异性= 85％），而运动诱发的血浆乳酸升高仅在MM患者的恒定工作量方案期间高于对照组（P ＜0.05;灵敏度＝ 27％;特异性＝ 86％）。这些发现表明，恒定工作量协议的诊断价值优于增量循环测试，但该测试对MM的敏感性低于对静止的乳酸和肌肉形态进行简单测试。 MM患者的周期测试仍然是重要的研究工具，但不应成为MM的标准诊断程序。

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