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首页> 外文期刊>Journal of neurology >Environmental, life-style, and physical precursors of clinical Parkinson's disease: recent findings from the Honolulu-Asia Aging Study.
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Environmental, life-style, and physical precursors of clinical Parkinson's disease: recent findings from the Honolulu-Asia Aging Study.

机译：帕金森氏病的环境，生活方式和物理前体：檀香山-亚洲老龄化研究的最新发现。

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BACKGROUND: Increased westernization with Japanese migration to the U. S. in the early 20(th) century is thought to have altered the risk of cardiovascular disease. Whether similar effects include changes in the risk of Parkinson's disease (PD) is not clear. This report describes the relations between environmental, life-style, and physical attributes and the incidence of PD that have been observed in the Honolulu-Asia Aging Study. METHODS: Beginning in 1965, environmental, life-style, and physical attributes were recorded at selected examinations in a cohort of 8,006 Japanese-American men. Subjects were followed for clinical PD. FINDINGS: During 30 years of follow- up, PD was observed in 137 men. Overall incidence (7.1/10,000 person-years) was generally higher than in Asia and similar to rates observed in Europe and the U. S. Precursors of PD included constipation, adiposity, years worked on a sugar or pineapple plantation, years of exposure to pesticides, and exposure to sugar cane processing. Factors showing an inverse association with PD included coffee intake and cigarette smoking. Among dietary factors, carbohydrates increased the risk of PD while the intake of polyunsaturated fats appeared protective. Total caloric intake, saturated and monounsaturated fats, protein, niacin, riboflavin, beta-carotene, vitamins A, B, and C, dietary cholesterol, cobalamin, alpha-tocopherol, and pantothenic acid showed no clear relation with clinical PD. INTERPRETATION: Findings suggest that several environmental, life-style, and physical attributes appear to be precursors of PD. Whether patterns of precursors can be used to identify individuals at high risk of future PD or can broaden the scope of early interventions or recruitment into neuroprotective trials warrants further study.
机译：背景：人们认为20世纪初期日本移民到美国后，西化程度增加，已经改变了患心血管疾病的风险。目前尚不清楚类似的影响是否包括帕金森氏病（PD）风险的改变。本报告介绍了在檀香山-亚洲老龄化研究中观察到的环境，生活方式和物理属性与PD发生率之间的关系。方法：从1965年开始，在针对8006名日裔美国人的队列中的选定考试中记录了环境，生活方式和身体属性。追踪受试者的临床PD。结果：在30年的随访中，有137例男性出现PD。总发病率（7.1 / 10,000人年）通常高于亚洲，与欧洲和美国的发病率相似，PD的前兆包括便秘，肥胖症，从事糖或菠萝种植的年限，接触农药的年限以及接触甘蔗加工。与PD呈负相关的因素包括咖啡摄入量和吸烟。在饮食因素中，碳水化合物增加发生PD的风险，而多不饱和脂肪的摄入则起到保护作用。总热量摄入，饱和和单不饱和脂肪，蛋白质，烟酸，核黄素，β-胡萝卜素，维生素A，B和C，饮食中的胆固醇，钴胺素，α-生育酚和泛酸与临床PD无明显关系。解释：研究结果表明，几种环境，生活方式和物理属性似乎是PD的先兆。前体的模式是否可用于识别未来PD的高风险人群，还是可以扩大早期干预或招募进入神经保护性试验的范围，值得进一步研究。

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