...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of neurology >Cortical thinning in drug-naive Parkinson's disease patients with depression
【24h】

Cortical thinning in drug-naive Parkinson's disease patients with depression

机译：初次接受药物治疗的帕金森氏症抑郁症患者的皮质变薄

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To shed more light on the contribution of brain structural changes to PD-related depressive symptoms, this study conducted cortical thickness analysis in drug-naive PD patients with and without depression. We recruited 27 PD patients with depression (PD-Dep), 29 PD patients without depression (PD-NDep), and 56 normal controls. T1 weighted magnetic resonance imaging and surface-based morphometric analyses were performed to examine morphometric abnormalities in PD patients and their relationship to depression. We found decreased thickness in the left prefrontal cortex in PD-Dep group compared with PD-NDep group. No significant difference was found between PD patients and controls. In addition, we found there is a trend of inverse correlation between the structural changes and the score of depressive symptom in depressed PD patients. This study demonstrates that cortical thinning in prefrontal area in drug-naive PD patients with depression and highlights the critical role of prefrontal region in the depression associated with PD.
机译：为了更清楚地了解大脑结构变化对与PD相关的抑郁症状的影响，该研究对无药和无抑郁药物的PD患者进行了皮层厚度分析。我们招募了27名患有抑郁症的PD患者（PD-Dep），29名无抑郁症的PD患者（PD-NDep）和56名正常对照。进行了T1加权磁共振成像和基于表面的形态分析，以检查PD患者的形态异常及其与抑郁的关系。我们发现与PD-NDep组相比，PD-Dep组左前额叶皮层厚度减少。 PD患者和对照组之间没有发现显着差异。此外，我们发现抑郁症PD患者的结构变化与抑郁症状评分之间存在负相关的趋势。这项研究表明，在单纯药物治疗的PD患者中，前额叶皮层变薄，并突出了前额叶区域在与PD相关的抑郁症中的关键作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号