Do patients with Parkinson's disease benefit from embryonic dopamine cell transplantation?

Freed CR; Leehey MA; Zawada M; Bjugstad K; Thompson L; Breeze RE

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Do patients with Parkinson's disease benefit from embryonic dopamine cell transplantation?

机译：帕金森氏病患者会从胚胎多巴胺细胞移植中受益吗？

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Embryonic dopamine cell transplants survive in nearly all patients regardless of age and without immunosuppression. Transplants can improve Parkinson "off" symptoms up to the best effects of L-dopa observed preoperatively. They cannot improve the "best on" state. Transplants appear to survive indefinitely. In 10 to 15% of patients, transplants can reproduce the dyskinetic effects of L-dopa even after discontinuing all L-dopa. Neurotransplantation should be tried earlier in the clinical course of Parkinson's to see if earlier intervention can prevent progression of the disease, particularly the dyskinetic responses seen after longterm L-dopa treatment.

机译：胚胎多巴胺细胞移植几乎可以在所有患者中生存，无论其年龄和免疫抑制情况如何。移植可以改善帕金森“关闭”症状，直至在术前观察到左旋多巴的最佳效果。他们无法改善“最佳状态”。移植似乎可以无限期地生存。在10％到15％的患者中，即使停用所有L-多巴，移植物也可以重现L-多巴的运动障碍作用。在帕金森氏症的临床过程中应尽早尝试神经移植，以了解早期干预是否可以预防疾病的进展，尤其是长期左旋多巴治疗后出现的运动障碍反应。

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来源
《Journal of neurology》 |2003年第3期|共3页
作者
Freed CR; Leehey MA; Zawada M; Bjugstad K; Thompson L; Breeze RE;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Levodopa; Dopamine; Homologous Grafts; Cell Transplantation; Parkinson Disease; 左旋多巴; 多巴胺; 细胞移植; 帕金森病;

机译：Levodopa;Dopamine;Homologous Grafts;Cell Transplantation;Parkinson Disease;左旋多巴;多巴胺;细胞移植;帕金森病;

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专利

1. Do patients with Parkinson's disease benefit from embryonic dopamine cell transplantation? [J] . Freed CR, Leehey MA, Zawada M, Journal of neurology . 2003,第Suppla3期

机译：帕金森氏病患者会从胚胎多巴胺细胞移植中受益吗？
2. Multitracer Assessment of Dopamine Function After Transplantation of Embryonic Stem Cell-Derived Neural Stem Cells in a Primate Model of Parkinson's Disease [J] . Muramatsu SI, Okuno T, Suzuki Y, Synapse . 2009,第7期

机译：帕金森病灵长类动物模型中胚胎干细胞源性神经干细胞移植后多巴胺功能的多示踪评估
3. The Role of Lmx1a in the Differentiation of Human Embryonic Stem Cells into Midbrain Dopamine Neurons in Culture and After Transplantation into a Parkinson's Disease Model§ [J] . Jingli Cai, Angela Donaldson, Ming Yang, STEM CELLS . 2009,第1期

机译：Lmx1a在人类胚胎干细胞向培养中脑多巴胺神经元分化以及移植到帕金森病模型后的作用 §
4. REGIONAL CEREBRAL BLOOD FLOW BY BRAIN SPECT ~(99)Tc~m-HMPAO IN PATIENTS WITH PARKINSON'S DISEASE BEFORE AND AFTER FOETAL TISSUE TRANSPLANTATION: REPORT OF FOUR CASES [C] . C. SANCHEZ-CATASUS, N. RODRIGUEZ, L. ALVAREZ, Tomography in nuclear medicine . 1995

机译：胎儿组织移植前后帕金森氏病患者脑部〜（99）Tc〜m-HMPAO脑区血流的报告：四例报告
5. The potential for hope: Parkinson's patients look to embryonic stem cells for a possible cure. [D] . Hinojosa, Alexandra. 2010

机译：潜在的希望：帕金森氏症患者希望使用胚胎干细胞来治愈。
6. Will embryonic stem cells be a useful source of dopamine neurons for transplant into patients with Parkinsons disease? [O] . Curt R. Freed 2002

机译：胚胎干细胞会成为多巴胺神经元移植到帕金森氏病患者中的有用来源吗？
7. Will embryonic stem cells be a useful source of dopamine neurons for transplant into patients with Parkinson's disease? [O] . Freed, Curt R. 2002

机译：胚胎干细胞会成为多巴胺神经元移植到帕金森氏病患者中的有用来源吗？

Do patients with Parkinson's disease benefit from embryonic dopamine cell transplantation?

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