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首页> 外文期刊>Journal of neurology >A study of the mechanisms of normal-appearing white matter damage in multiple sclerosis using diffusion tensor imaging--evidence of Wallerian degeneration.
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A study of the mechanisms of normal-appearing white matter damage in multiple sclerosis using diffusion tensor imaging--evidence of Wallerian degeneration.

机译：使用扩散张量成像研究多发性硬化症中正常出现的白质损伤的机制-沃勒变性的证据。

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摘要

Diffusion tensor imaging (DTI) investigates brain tissue microstructure in vivo. In multiple sclerosis (MS) Wallerian degeneration of axons traversing focal lesions is a potential mechanism of damage in normal-appearing white matter. In vivo evidence for this hypothesis is limited. The present study investigated the relationship between DTI-derived indices in the normal-appearing corpus callosum (CC) and the lesion loads (LLs) in connected cerebral regions. DTI was performed in 39 MS patients and in 21 age-matched controls. Fractional anisotropy (FA) and mean diffusivity (MD) were estimated in the genu, body and splenium of CC. Patients showed lower FA and higher MD in the CC than controls and both correlated with the total LL (r = -0.56 and r = 0.54, p < 0.0001). The LL of individual cerebral lobes correlated with both FA and MD in the corresponding callosal regions, with the body showing the strongest correlations with frontal and parietal LL (p < 0.0001). The strong correlations between DTI indices in the CC and the extent of lesions in connected brain regions support the hypothesis that Wallerian degeneration of axons transected by remote, but connected focal lesions, is an important pathogenic mechanism of damage in MS.
机译：扩散张量成像（DTI）研究体内脑组织的微观结构。在多发性硬化症（MS）中，遍历局灶性病变的轴突沃勒氏变性是正常出现的白质受损的潜在机制。该假说的体内证据有限。本研究调查了正常出现的体（CC）中DTI派生指标与相连大脑区域的病变负荷（LLs）之间的关系。在39例MS患者和21例年龄匹配的对照组中进行了DTI。在CC的属，体和脾中估计了分数各向异性（FA）和平均扩散率（MD）。患者在CC中显示出较低的FA和较高的MD，且均与总LL相关（r = -0.56和r = 0.54，p <0.0001）。单个脑叶的LL与相应call体区域的FA和MD相关，而身体与额叶和顶叶LL的相关性最强（p <0.0001）。 CC中DTI指数与相连大脑区域病变程度之间的强相关性支持以下假说，即远端但相连的局灶性病变横切的Wallerian轴突变性是MS损伤的重要发病机制。

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