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首页> 外文期刊>Journal of neurology >Proton magnetic resonance spectroscopy in frontotemporal dementia.
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Proton magnetic resonance spectroscopy in frontotemporal dementia.

机译：额颞痴呆的质子磁共振波谱。

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摘要

This study of frontotemporal dementia (FTD) was carried out to determine whether MR spectroscopy can provide an in vivo marker for the neuronal loss and gliosis that occur in this condition. We compared spectra in frontal and temporal regions known to be affected early in the course of the disease with spectra in the parietal lobe that is spared until late stages of FTD. We were interested in the relative concentrations of two compounds, NAA (a marker of neuronal integrity) and mI (a marker of gliosis), expressed as ratios to creatine (a relatively stable brain constituent). MR spectroscopy was performed on the temporal, parietal, and anterior cingulate cortices of five patients with the established semantic dementia form of FTD, two patients with the frontal form of FTD and 13 age matched controls. Structural MRI and neuropsychometry were also performed. Patients with FTD had reduced NAA/Cr in frontal and temporal, but not parietal lobes. The two patients with the frontal form of FTD had increased mI/Cr in their cingulate cortices. These data show for the first time that MR spectroscopy can reveal regionally selective abnormalities in patients with FTD. This opens up the possibility of using MR spectroscopy as a clinical tool to identify earlier presentations of the condition.
机译：进行了额颞叶痴呆（FTD）的研究，以确定MR光谱是否可以为这种情况下发生的神经元丢失和神经胶质增生提供体内标记。我们将已知在疾病早期受到影响的额叶和颞叶区域的频谱与顶叶的频谱进行了比较，该频谱一直保留到FTD的后期。我们对两种化合物的相对浓度感兴趣，NAA（神经元完整性的标志物）和mI（神经胶质化的标志物）相对于肌酸（相对稳定的大脑成分）的比率表示。 MR光谱是对5例已建立语义性痴呆形式的FTD，2例具有正面形式的FTD和13个年龄匹配的对照的颞，顶和前扣带回皮层进行的。还进行了结构MRI和神经心理测量。 FTD患者的额叶和颞叶NAA / Cr降低，但顶叶没有降低。两名患有FTD额叶形式的患者的扣带状皮质mI / Cr升高。这些数据首次表明，MR光谱可以揭示FTD患者的区域选择性异常。这就开辟了将MR光谱法用作临床工具来识别疾病早期表现的可能性。

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