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首页> 外文期刊>Journal of neurology >Change in artistic expression related to subthalamic stimulation.
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Change in artistic expression related to subthalamic stimulation.

机译:与丘脑刺激相关的艺术表现形式的变化。

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Sirs: The dopamine systems do not only control movement but also play a major role in reward and motivation . Parkinson disease (PD) patients on high dopaminergic treatment might occasionally develop behavioural disorders characterised by an increase of dopamine intake and a constant search for pleasure . Such patients also show a tendency for hypomanic and compulsive behavioural disorders such as gambling in casinos, displaying hypersexual behaviour, spending too much money on shopping, gaining weight because of excessive eating or drinking. Subthalamic stimulation in PD has been shown to mimic the psychotropic activity of levodopa .Here we report a patient who developed a change in artistic expression after subthalamic stimulation. This 65-year-old architect with a 16-year history of PD was suffering from severe motor fluctuations. Mood fluctuated in parallel with his motor state while on a daily dosage of 1500mg levodopa, 15 mg ropinirole, 1 mg cabergoline and 10 mg selegiline. As an architect he was frequently painting and before surgery his themes were exclusively architectural.
机译:主席先生:多巴胺系统不仅控制运动,而且在奖励和动机中也起着重要作用。接受高多巴胺能治疗的帕金森病(PD)患者可能偶尔会出现以多巴胺摄入量增加和不断寻求愉悦为特征的行为障碍。这些患者还表现出躁狂和强迫性行为失调的趋势,例如在赌场赌博,表现出性欲过剩的行为,在购物上花太多钱,由于饮食过多而体重增加。 PD中的丘脑刺激已被证明可模仿左旋多巴的精神活动。在此我们报道了一名患者,在丘脑刺激后其艺术表达发生了变化。这位65岁,PD病史长达16年的建筑师患有严重的运动波动。每天服用1500毫克左旋多巴,15毫克罗匹尼罗,1毫克卡麦角林和10毫克司来吉兰时,情绪与运动状态平行波动。作为建筑师,他经常绘画,在手术之前,他的主题完全是建筑。

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