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首页> 外文期刊>Journal of neurology >Posterior circulation ASPECTS on diffusion-weighted MRI can be a powerful marker for predicting functional outcome.
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Posterior circulation ASPECTS on diffusion-weighted MRI can be a powerful marker for predicting functional outcome.

机译：弥散加权MRI上的后循环ASPECTS可以作为预测功能预后的有力标志。

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There are few studies regarding functional outcome and lesion extent on diffusion-weighted MRI (DWI) in patients with posterior circulation (PC) infarction. The aim of our study was to assess whether a newly proposed posterior circulation Alberta Stroke Program Early CT Score (pc-ASPECTS) on DWI is useful for predicting functional outcome in PC patients. One hundred thirty-two patients with first-ever ischemic stroke in the posterior circulation within 24 h of onset who were admitted to our hospital were enrolled in the study. We compared background characteristics, vital signs, laboratory data, and MRI findings between favorable (F) and unfavorable (U) outcome groups at 3 months, according to the modified Rankin Scale (mRS). The F and U groups were defined as having a mRS of 0-2 and 3-6, respectively. pc-ASPECTS was scored by DWI obtained 12-36 h after onset. Ninety-eight patients (74.2%) were classified into the F group and 34 patients (25.8%) into the U group. On univariate analysis, F group patients were younger, had lower National Institutes of Health Stroke Scale (NIHSS) score at entry, and a lower rate of early neurological deterioration (END) and cardioembolic stroke than U group patients. On MRI, F group patients had lower leukoaraiosis and medial temporal atrophy score and higher pc-ASPECTS score on DWI compared to U group patients. Multiple logistic regression analysis revealed NIHSS (p < 0.001), END (p = 0.0057), pc-ASPECTS (p < 0.001), and leukoaraiosis (p = 0.0091) as independent predictors of functional outcome. pc-ASPECTS appears to be a powerful marker for predicting functional outcome, along with clinical severity and END. Leukoaraiosis may also be an independent predictor of functional outcome.
机译：关于后循环（PC）梗死患者的弥散加权MRI（DWI）的功能结局和病变范围的研究很少。我们研究的目的是评估针对DWI的新提议的后循环艾伯塔中风计划早期CT评分（pc-ASPECTS）是否可用于预测PC患者的功能预后。入选本院的24例发病后24小时内有史以来首次后脑缺血性卒中的患者入选本研究。根据改良的兰金量表（mRS），我们比较了3个月时良好（F）和不利（U）结果组之间的背景特征，生命体征，实验室数据和MRI发现。 F和U组的mRS分别定义为0-2和3-6。发病后12-36小时通过DWI对pc-ASPECTS评分。将98例患者（74.2％）分为F组，将34例患者（25.8％）分为U组。单因素分析显示，F组患者较U组患者年轻，入院时美国国立卫生研究院卒中量表（NIHSS）得分较低，早期神经系统恶化（END）和心脏栓塞性中风发生率较低。在MRI上，与U组患者相比，F组患者在DWI上具有较低的白质软化症和内侧颞萎缩评分以及较高的pc-ASPECTS评分。多元逻辑回归分析显示，NIHSS（p <0.001），END（p = 0.0057），pc-ASPECTS（p <0.001）和白斑病（p = 0.0091）是功能预后的独立预测因子。 pc-ASPECTS似乎是预测功能结局以及临床严重程度和END的有力标记。白细胞增多症也可能是功能预后的独立预测因子。

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