...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of neurology >Freezing of gait in Parkinson's disease.
【24h】

Freezing of gait in Parkinson's disease.

机译：帕金森氏病的步态冻结。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Freezing of Gait (FOG) is one of the most disabling and least understood symptoms in Parkinson's disease (PD), and is usually observed in the advanced stage of the disease. FOG can be experienced on turning, in narrow spaces, whilst reaching a destination, and in stressful situations. FOG is commonly observed in the "off" state, but it can also be observed in the "on" state. Dual tasking (cognitive load) aggravates FOG. Visual or auditory cues often resolve FOG. Analysis of gait revealed that the rhythm of stepping suddenly jumps into high frequency (4-5 Hz) in FOG (hastening), and that floor reaction forces are disregulated. Stride-to-stride variability is increased in FOG. Hastening phenomenon was reported not only in PD patients but also in patients with striatal lesions. The basal ganglia and its frontal projections may be one of the essential lesion sites for FOG.A recent study using single-photon emission tomography (SPECT) revealed enhanced lateral premotor cortex (PMC) activity during paradoxical gait in PD, suggesting that PMC can compensate for the impaired function of the medial frontal cortex when cued by visual input. Treatment of FOG includes behavioural, medical, and surgical approaches. Tricks of all kinds (including external cues) are effective therapeutic approaches. If FOG occurs predominantly in the "off" state, dopaminergic therapy can be increased. For "on" freezing or if "on" response is otherwise optimised, the dose of the dopaminergic agent may be manipulated, but it could lead to the deterioration of parkinsonism. Deep brain stimulation of the STN often alleviates FOG in the "off" state.
机译：步态冻结（FOG）是帕金森氏病（PD）中最致残和了解最少的症状之一，通常在疾病的晚期阶段观察到。 FOG可以在狭窄的空间，到达目的地和压力很大的环境中转弯。 FOG通常在“关闭”状态下观察到，但也可以在“开启”状态下观察到。双重任务（认知负担）加重了FOG。视觉或听觉提示通常可以解决FOG。步态分析表明，步态的节奏突然跳入FOG（加速）中的高频（4-5 Hz），并且地面反作用力被忽略。 FOG的步幅差异增加。据报道不仅在PD患者中而且在纹状体病变患者中都有加速现象。基底节及其额突可能是FOG的重要病变部位之一。最近一项使用单光子发射断层扫描（SPECT）的研究表明，PD悖论步态期间增强了侧前运动皮层（PMC）活性，表明PMC可以补偿当视觉输入提示时，内侧额叶皮质的功能受损。 FOG的治疗包括行为，医学和手术方法。各种技巧（包括外部提示）都是有效的治疗方法。如果FOG主要以“关闭”状态发生，则可以增加多巴胺能治疗。对于“ on”冻结或如果“ on”响应被最佳化，可以控制多巴胺能药物的剂量，但可能导致帕金森综合症恶化。对STN的深层大脑刺激通常可以缓解“关闭”状态下的FOG。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号