Depression and psychiatric symptoms preceding onset of dementia in a family with early-onset Alzheimer disease with a novel PSEN1 mutation.

Kasuga K; Ohno T; Ishihara T

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Depression and psychiatric symptoms preceding onset of dementia in a family with early-onset Alzheimer disease with a novel PSEN1 mutation.

机译：在患有新型PSEN1突变的早发性早老性阿尔茨海默病的家庭中，痴呆症发作之前的抑郁和精神症状。

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PSEN1 mutations are the most common cause of autosomal dominant early-onset familial Alzheimer disease (EO-FAD) in diverse ethnic groups [1-3]. Cognitive decline is a cardinal clinical feature in patients with PSEN1 mutations; however, various accompanying clinical manifestations have been reported [4]. We report a family with a novel PSEN1 mutation who developed depression and psychiatric symptoms preceding the onset of dementia.

机译：在不同种族中，PSEN1突变是常染色体显性遗传早期家族性阿尔茨海默病（EO-FAD）的最常见原因[1-3]。认知功能下降是PSEN1突变患者的主要临床特征。然而，已经报道了各种伴随的临床表现[4]。我们报告一个新的PSEN1突变的家庭，在痴呆症发作之前就出现了抑郁和精神症状。

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《Journal of neurology》 |2009年第8期|共3页
作者
Kasuga K; Ohno T; Ishihara T;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
symptoms lt; 1gt; novel; Dementia; Mutation; Family;

机译：症状1;新发;痴呆;突变;家庭;

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专利

1. Depression and psychiatric symptoms preceding onset of dementia in a family with early-onset Alzheimer disease with a novel PSEN1 mutation. [J] . Kasuga K, Ohno T, Ishihara T Journal of neurology . 2009,第8期

机译：在患有新型PSEN1突变的早发性早老性阿尔茨海默病的家庭中，痴呆症发作之前的抑郁和精神症状。
2. Diagnostic Approach of Early-Onset Dementia with Negative Family History: Implications from Two Cases of Early-Onset Alzheimer's Disease with De Novo PSEN1 Mutation [J] . Liu Jia, Wang Qianqian, Jing Donglai, Journal of Alzheimer's disease: JAD . 2019,第2期

机译：具有负家庭历史的早期发病性痴呆症的诊断方法：两种患者早熟阿尔茨海默病与DE Novo PSEN1突变的影响
3. Identification of a novel PSEN1 mutation (Leu232Pro) in a Korean patient with early-onset Alzheimer's disease and a family history of dementia [J] . Jiyun Park, Seong Soo A. An, Vo Van Giau, Neurobiology of Aging: Experimental and Clinical Research . 2017,第期

机译：鉴别韩国患者的新型PSEN1突变（Leu232Pro），早期患者和痴呆症的家族史
4. Communication of brain network core connections altered in behavioral variant frontotemporal dementia but possibly preserved in early-onset Alzheimer's disease [C] . Madelaine Daianu, Neda Jahanshad, Mario F. Mendez, Conference on image processing . 2015

机译：行为变异额颞痴呆中脑网络核心连接的交流发生改变，但可能保留在早发性阿尔茨海默氏病中
5. Autobiographical accounts of early-onset alzheimer's disease: Obituaries of the living dead?. [D] . Stanley, Daina. 2013

机译：早期阿尔茨海默氏病的自传体记载：活死人的Ob告？
6. A Pathogenic Variant p.Phe177Val in PSEN1 Causes Early-Onset Alzheimer’s Disease in a Chinese Family [O] . Bin Jiang, Min Bi, Jun Li, 2020

机译：PSEN1的致病变异P.phe177Val在中国家庭中引起早起的阿尔茨海默病
7. First episodes of behavioral symptoms in Alzheimer's disease patients at age 90 and over, and early-onset Alzheimer's disease: Comparison with senile dementia of Alzheimer's type [O] . KOJI HORI, TATSURO ODA, TOSHIYASU ASAOKA, 2005

机译：阿尔茨海默病患者患者在90岁及以上患者的第一次行为症状发作，早上的Alzheimer疾病：与阿尔茨海默氏症的老年痴呆症相比

Depression and psychiatric symptoms preceding onset of dementia in a family with early-onset Alzheimer disease with a novel PSEN1 mutation.

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