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首页> 外文期刊>Journal of neurology >Is there a delayed gastric emptying of patients with early-stage, untreated Parkinson's disease? An analysis using the 13C-acetate breath test.
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Is there a delayed gastric emptying of patients with early-stage, untreated Parkinson's disease? An analysis using the 13C-acetate breath test.

机译：未经治疗的早期帕金森氏病患者的胃排空是否延迟？使用13C-乙酸呼气试验进行分析。

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During the pre-symptomatic stage of Parkinson's disease (PD), the idiopathic PD related abnormal synuclein immunostaining is confined to the medulla oblongata and olfactory bulb, according to Braak. In the study of the enteric nervous system of PD, it has reported that Lewy bodies were found in the Auerbach's and Meissner's plexuses. These lesions may cause dysfunction of the gastrointestinal tract (GI) as pre-clinical symptoms of PD. However, because L: -dopa therapy itself may worsen the symptoms of the digestive tract function, it is needed to evaluate the gastrointestinal tract function in patients with early-stage, untreated (de novo) PD. In the present study, using the (13)C-acetate breath test ((13)C-ABT), we investigated gastric emptying in 20 untreated, early-stage PD patients and 40 treated, advanced-stage PD patients, and 20 healthy volunteers. Gastric emptying was examined by the (13)C-ABT [the half emptying time (HET), the peak time of the (13)C% dose-excess curve (T (max))]. The T (max) and HET of gastric emptying as assessed using the (13)C-ABT was significantly delayed in untreated, early-stage PD patients as compared to the controls (P < 0.001). The T (max) and HET of gastric emptying were not significantly delayed in untreated, early-stage PD patients as compared to treated, advanced-stage PD patients. The results demonstrated that delay in gastric emptying did not differ between untreated, early-stage and treated, advanced-stage PD patients. Gastric emptying of untreated, early-stage PD is already delayed. Delayed gastric emptying may be one of markers of the pre-clinical stage of PD.
机译：Braak认为，在帕金森病（PD）的症状发作前阶段，特发性PD相关的异常突触核蛋白免疫染色仅限于延髓和嗅球。在PD肠道神经系统的研究中，据报道，在Auerbach和Meissner的神经丛中发现了路易体。这些病变可能会导致PD的临床前症状，即胃肠道功能障碍。但是，由于L：-多巴疗法本身可能会使消化道功能的症状恶化，因此有必要评估未经治疗（从头开始）的早期PD患者的胃肠道功能。在本研究中，我们使用（13）C-乙酸呼气试验（（13）C-ABT），调查了20例未经治疗的早期PD患者和40例接受治疗的晚期PD患者以及20例健康的胃排空志愿者。用（13）C-ABT [半空时间（HET），（13）C％剂量过量曲线的峰值时间（T（最大））]检查胃排空。与对照组相比，使用（13）C-ABT评估的未经治疗的早期PD患者的胃排空的T（最大）和HET明显延迟（P <0.001）。与治疗晚期PD患者相比，未经治疗的早期PD患者的胃排空的T（max）和HET没有明显延迟。结果表明，未治疗的早期和晚期PD患者之间的胃排空延迟没有差异。未经治疗的早期PD的胃排空已经延迟。胃排空延迟可能是PD临床前阶段的标志之一。

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