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首页> 外文期刊>Clinics in dermatology >Advancement in skin aging: the future cosmeceuticals.
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Advancement in skin aging: the future cosmeceuticals.

机译：皮肤老化的进展：未来的药妆品。

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摘要

Aging is a multifactorial process defined as the accumulation of damage. The aging of the skin is characterized by specific clinical end points, the cause of which is not always thoroughly understood. The skin is exposed to environmental aggressions and the reactive oxygen species produced during cellular metabolism. Damage to the cellular and extracellular components of the skin can be avoided or removed by the appropriate topical application of active ingredients. Sunscreens are essential to avoid damage from the most important damaging environmental agent: solar radiation. Liposomes containing deoxyribonucleic acid repair enzymes and accelerate the endogenous removal of pyrimidine dimers after exposure to ultraviolet radiation. Specific antioxidants reduce the rate of formation of secondary ultraviolet-induced damages, particularly those induced by singlet oxygen. Anti-inflammatory agents, immunostimulants, and enhancers of molecular and cellular detoxification could enter the panoply of new cosmeceuticals to avoid age spots, dark circles, wrinkles, and other clinical aspects of skin aging.
机译：老化是定义为损伤累积的多因素过程。皮肤的衰老以特定的临床终点为特征，其原因并不总是能被彻底了解。皮肤受到环境的侵害，并在细胞代谢过程中产生活性氧。通过适当局部施用活性成分，可以避免或消除对皮肤细胞和细胞外成分的损害。防晒霜对于避免受到最重要的破坏性环境因素（太阳辐射）的损害至关重要。含有脱氧核糖核酸的脂质体可修复酶，并在暴露于紫外线辐射后加速嘧啶二聚体的内源性去除。特定的抗氧化剂可降低紫外线引起的继发性损伤的形成速度，特别是由单线态氧引起的损伤。抗炎剂，免疫刺激剂以及分子和细胞排毒的增强剂可以进入新的药妆品中，避免出现老年斑，黑眼圈，皱纹和皮肤衰老的其他临床方面。

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