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首页> 外文期刊>Journal of neurology >HLA class I and class II profiles of patients presenting with Sydenham's chorea.
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HLA class I and class II profiles of patients presenting with Sydenham's chorea.

机译：Sydenham舞蹈病患者的HLA I级和II级特征。

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摘要

Sydenham's chorea (SC) may occur in rheumatic fever (RF) patients without arthritis and carditis. In this study we typed HLA antigens and alleles in patients presenting with the distinct major clinical manifestations of RF, i.e., chorea, carditis, or arthritis, in population and family studies. We evaluated 91 patients with RF for HLA-A, HLA-B, and HLA-DR antigens; of these, 33 had pure chorea, 26 pure carditis, 16 pure arthritis, and 16 carditis plus arthritis. We also typed 24 SC patients and their unaffected siblings for HLA-DRB1 and HLA-DQB1 alleles using molecular methods. HLA-B49 and HLA-DR1 antigens were overrepresented in the total group of patients with RF and in all the subgroups studied, excluding the SC subgroup in which the frequency of HLA-DR1 antigen was not increased. The frequencies of the HLA-DRB1 and HLA-DQB1 alleles in patients with pure chorea were not significantly different from those observed in controls. Similarly, the frequencies of HLA class II alleles in SC patients did not differ significantly from those observed in unaffected siblings. These findings show that immunogenetic susceptibility to RF varies according to the major clinical manifestation presented by the patient.
机译：Sydenham舞蹈病（SC）可能发生在风湿热（RF）患者中，而没有关节炎和心脏病。在这项研究中，我们在人群和家庭研究中对表现出RF的主要临床表现（即舞蹈病，心肌炎或关节炎）的患者进行了HLA抗原和等位基因分型。我们评估了91例RF患者的HLA-A，HLA-B和HLA-DR抗原。其中33例患有单纯性舞蹈症，26例患有纯净的心脏炎，16例患有纯净的关节炎，16例患有心脏炎加关节炎。我们还使用分子方法为HLA-DRB1和HLA-DQB1等位基因分型了24名SC患者及其未受影响的兄弟姐妹。 HLA-B49和HLA-DR1抗原在所有RF患者组和所有研究亚组中均过高，但SC子组中HLA-DR1抗原的频率没有增加。单纯性舞蹈病患者的HLA-DRB1和HLA-DQB1等位基因频率与对照组相比无显着差异。同样，SC患者中HLA II类等位基因的频率与未患病兄弟姐妹中观察到的频率没有显着差异。这些发现表明，RF的免疫遗传易感性根据患者呈现的主要临床表现而有所不同。

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