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首页> 外文期刊>Journal of neurology >Hypoglycemic encephalopathy: A case series and literature review on outcome determination
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Hypoglycemic encephalopathy: A case series and literature review on outcome determination

机译：降血糖性脑病：一个病例系列和关于结局测定的文献综述

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Data on clinical long-term outcome after the acute phase of hypoglycemic encephalopathy (HE) using validated outcome scales is currently unavailable. Here we report the results of a systematic literature search for studies on HE and data on long-term outcome in patients with HE admitted to three Charité hospitals between January 2005 and July 2010. HE was defined as coma/stupor and blood glucose levels <50 mg/dl on admission, persistence of coma/stupor for ≥24 h despite normalization of blood glucose levels, and exclusion of any other cause of coma/stupor. Outcome was assessed using the modified Rankin scale (mRS), Glasgow Outcome Scale (GOS), and Barthel index (BI). Fifteen patients were included, with a mean age of 60 years (range 29-79). Two were lost to follow-up. Of the remaining 13 patients, six had died (46 %). In the seven survivors, the median mRS score was 0 (range 0-5), median GOS score was 5 (range 2-5), and median BI was 100 (range 0-100). MRIs made in the acute phase were available for three patients and revealed no obvious relation between lesion size or pattern and clinical outcome. To our knowledge, this is the first case series using validated clinical scoring systems to determine clinical long-term outcome after HE. The results suggest that mortality is high, but long-term survival with little or no disability is possible and can be observed in the majority of survivors. Risk of death or poor outcome does not seem to be related to MRI features in the acute phase but rather to other presumably medical factors.
机译：目前尚无使用经过验证的结果量表得出的低血糖性脑病（HE）急性期后临床长期结果的数据。在这里，我们报告了一项系统性文献检索的结果，该研究检索了2005年1月至2010年7月在三所Charité医院住院的HE患者的HE和长期结局数据。HE被定义为昏迷/木僵且血糖水平<50入院时mg / dl，尽管血糖水平正常，昏迷/昏迷持续≥24小时，并且排除了其他原因引起的昏迷/昏迷。使用改良的兰金量表（mRS），格拉斯哥结果量表（GOS）和巴特尔指数（BI）评估结果。纳入15例患者，平均年龄60岁（范围29-79）。有两人失踪。其余13例患者中有6例死亡（46％）。在这七个幸存者中，mRS的中位数为0（范围为0-5），GOS的中位数为5（范围为2-5），BI的中位数为100（范围为0-100）。急性期的MRI可用于三名患者，并且显示病变大小或模式与临床结局之间无明显关系。据我们所知，这是使用经过验证的临床评分系统确定HE后临床长期预后的第一个病例系列。结果表明死亡率很高，但是长期生存而很少或没有残疾是可能的，并且在大多数幸存者中都可以观察到。死亡或预后不良的危险似乎与急性期的MRI特征无关，而与其他可能的医学因素有关。

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