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首页> 外文期刊>Journal of neurology >Substance abuse may be a risk factor for earlier onset of Huntington disease.
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Substance abuse may be a risk factor for earlier onset of Huntington disease.

机译：物质滥用可能是亨廷顿病较早发作的危险因素。

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摘要

Environmental factors may contribute as much as one-third of the variance in Huntington disease (HD) age of onset. Substance abuse is a risk factor for other neurodegenerative disorders; however, whether substance abuse influences HD age of onset is not well established. This study investigated the relationships between alcohol, drug, and tobacco abuse and HD age of onset in 136 participants with symptomatic HD. CAG repeat length was used as a covariate in all analyses, as it represents the most significant determinant of HD age of onset. The relationship between substance abuse, HD age of onset, and sex was also examined, as women may experience greater medical harm from substance abuse. Lifetime alcohol abuse and lifetime drug abuse were associated with earlier age of HD onset; a similar trend was seen for current tobacco abuse. For women, lifetime alcohol abuse was associated with earlier onset of HD, with a similar trend for lifetime drug abuse. However, alcohol, drug, and tobacco abuse were not significantly associated with age of onset in men. Further work is needed to determine whether substance abuse is a causative risk factor for earlier onset of HD, and why the environmental factors associated with age of onset vary by sex.
机译：在亨廷顿病（HD）发病年龄中，环境因素可能占差异的三分之一。药物滥用是其他神经退行性疾病的危险因素;然而，吸毒是否影响HD发病年龄尚不清楚。这项研究调查了136名有症状HD参与者中酒精，毒品和烟草滥用与HD发病年龄之间的关系。 CAG重复长度在所有分析中均用作协变量，因为它代表HD发病年龄的最重要决定因素。还检查了药物滥用，HD发病年龄和性别之间的关系，因为妇女可能会因滥用药物而遭受更大的医疗伤害。终生酗酒和终生滥用毒品与HD发病年龄早有关。当前的烟草滥用也有类似的趋势。对于女性而言，终生酗酒与HD发病较早有关，终生滥用毒品的趋势也相似。但是，酗酒，吸毒和吸烟与男性发病年龄没有明显关系。需要做进一步的工作来确定滥用药物是否是HD较早发作的致病危险因素，以及与发病年龄相关的环境因素为何随性别而变化。

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