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首页> 外文期刊>Journal of neurology >Environmental dependency behaviours in frontotemporal dementia: have we been underrating them?
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Environmental dependency behaviours in frontotemporal dementia: have we been underrating them?

机译：额颞痴呆的环境依赖性行为：我们是否一直在低估它们？

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Environmental dependency (ED) behaviours, such as imitation behaviour (IB) and incidental utilization behaviour (UB), are considered pathognomonic of a frontal lesion and can play a unique role in diagnosing behavioural variant frontotemporal dementia (bvFTD). However, with only few focused observations of ED behaviour reported in earlier studies, their roles in the diagnosis of bvFTD have so far remained supportive. In this observational study, conducted in the cognitive clinic of a tertiary-care hospital, we explored the hypotheses that a focused and systematic search could uncover more ED behaviours in patients with bvFTD, and that the presence of ED behaviours such as incidental UB and IB should allow us to cleanly differentiate bvFTD from AD. Forty-one bvFTD patients and 75 probable AD patients, all diagnosed using accepted criteria, were seen by a neurologist and a neuropsychologist. Information regarding ED behaviour was obtained from the caregiver's history, observations for spontaneous behaviour and induction of the behaviour in the clinic. All ED behaviours were significantly more frequent in bvFTD compared with AD. UB (78?; 66? incidental) and IB (59?) occurred exclusively in bvFTD. Multi-pronged and focused clinical assessment contributed to the high frequency of ED behaviours. Nearly two-thirds of bvFTD patients, but none with AD, showed three or more ED behaviours. We concluded that ED behaviours are more common in bvFTD than is currently recognized. UB, IB or three ED behaviours, if present, could clearly differentiate bvFTD from AD. A focused search should consistently uncover ED behaviours in bvFTD patients.
机译：环境依赖性（ED）行为，例如模仿行为（IB）和附带利用行为（UB），被认为是额叶病变的病原学，可以在诊断行为变异额颞叶痴呆（bvFTD）中发挥独特作用。但是，在早期研究中，只有少数集中观察到的ED行为观察，到目前为止，它们在bvFTD诊断中的作用仍然是支持的。在这项由三级医院的认知诊所进行的观察性研究中，我们探讨了以下假设：有针对性的系统搜索可以发现bvFTD患者的更多ED行为，以及是否存在诸如UB和IB等ED行为应该可以让我们将bvFTD与AD完全区分开。神经科医生和神经心理学家共诊治了41例bvFTD患者和75例可能的AD患者，均采用公认的标准进行了诊断。有关ED行为的信息可从看护者的病史，自发行为的观察以及诊所行为的诱导中获得。与AD相比，bvFTD中所有ED行为的发生率均明显更高。 UB（78 ?; 66？附带）和IB（59？）仅发生在bvFTD中。多管齐下和重点突出的临床评估促进了ED行为的频繁发生。 bvFTD患者中近三分之二（但无AD）表现出3种或更多的ED行为。我们得出的结论是，在bvFTD中，ED行为比目前公认的更为普遍。如果存在UB，IB或三种ED行为，则可以清楚地区分bvFTD和AD。有针对性的搜索应该一致地发现bvFTD患者的ED行为。

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