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SPECT-DTPA as a tool for evaluating the blood-brain barrier in post-stroke seizures

机译：SPECT-DTPA作为评估中风后癫痫发作中血脑屏障的工具

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摘要

Stroke is a well-known cause for seizures in the adult population. Research in animal models indicates that abnormalities in the blood-brain barrier (BBB) permeability can play a role in the development of spontaneous seizures or status epilepticus. The integrity of the BBB was investigated in patients with late post-stroke seizures by performing DTPA-SPECT studies to evaluate the correlation of BBB dysfunction in late post-stroke seizures. All patients with late-onset post-cortical stroke seizures hospitalized during 2009-2010 underwent a brain DTPASPECT within 72 h of the first seizure and were compared to a control group of stroke patients without seizures. Twenty-eight patients were included in the study. Twelve out of 14 (85.7%) in the group of seizure post-stroke patients had a positive brain DTPA-SPECT showing disruption of the BBB in the region of the stroke respective to four patients out of 14 (28.6%) in the control group of stroke patients without seizures (p = 0.001). The results of this study suggest that there is a correlation between late post-stroke seizures and BBB disruption, as revealed by DTPA-SPECT examination. Perhaps, this finding could lead to the hypothesis that the BBB disruption can predict developing seizures in patients with cortical stroke.
机译：中风是成年人中癫痫发作的众所周知的原因。动物模型研究表明，血脑屏障（BBB）通透性异常可能在自发性癫痫发作或癫痫持续状态的发展中起作用。通过进行DTPA-SPECT研究以评估卒中后期晚期患者的BBB完整性，以评估卒中后期晚期BBB功能障碍的相关性。在2009年至2010年期间住院的所有迟发性皮质卒中后癫痫发作患者均在首次癫痫发作后72小时内接受了脑DTPASPECT检查，并与无癫痫发作的中风患者对照组进行了比较。本研究包括28名患者。卒中后癫痫发作患者中有14例中有12例（85.7％）的大脑DTPA-SPECT阳性，显示中风区域BBB破坏，对照组中14例中有4例（28.6％）无癫痫发作的中风患者（p = 0.001）。这项研究的结果表明，中风后癫痫发作与BBB破坏之间存在相关性，如DTPA-SPECT检查所揭示的。也许，这一发现可能导致这样的假设，即BBB破坏可以预测皮层卒中患者发生癫痫发作。

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