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首页> 外文期刊>Clinics in dermatology >Baboon syndrome and toxic erythema of chemotherapy: Fold (intertriginous) dermatoses
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Baboon syndrome and toxic erythema of chemotherapy: Fold (intertriginous) dermatoses

机译：狒狒综合征和化学毒性红斑：皱纹（三层间皮）

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Three decades ago, researchers described an eruption with a very characteristic distribution pattern that was confined to the buttocks and the intertriginous and flexor areas. They gave this reaction pattern one of the most unforgettable names in dermatology, baboon syndrome (BS), due to the characteristic, bright-red, well-demarcated eruption predominantly on the buttocks and genital area, reminiscent of the red bottom of a baboon. The authors described three cases provoked by ampicillin, nickel, and mercury. They were convinced that BS represented a special form of hematogenous or systemic contact-type dermatitis, but several important papers that appeared during the past decade disagreed and suggested that BS should be distinguished from hematogenous or systemic contact-type dermatitis. A new acronym, SDRIFE (symmetrical drug-related intertriginous and flexoral exanthema), was proposed along with five diagnostic criteria: (1) exposure to a systemically administered drug at the time of first or repeated doses (contact allergens excluded), (2) sharply demarcated erythema of the gluteal/perianal area and/or V-shaped erythema of the inguinal/perigenital area, (3) involvement of at least one other intertriginous/flexural fold, (4) symmetry of affected areas, and (5) absence of systemic symptoms and signs. Although there are merits to the arguments in favor of SDRIFE, many of us still prefer to use the wittier name baboon syndrome, and even more authors use both terms. We confess that we find it difficult to relinquish the term BS, which has served us so well for years; however, recognition, familiarity, and knowledge of the characteristics of this form of drug eruption must supersede sentimental attachment to a certain nomenclature and so, however reluctantly, we must embrace change.
机译：三十年前，研究人员描述了一种具有非常特征性分布模式的喷发，其分布仅限于臀部，三叉肌和屈肌区域。他们将这种反应模式命名为狒狒综合症（BS），是皮肤病学中最难忘的名称之一，这是因为特征性的鲜红色，界限分明的喷发主要发生在臀部和生殖器部位，让人联想到狒狒的红底。作者描述了由氨苄西林，镍和汞引起的三例。他们确信BS代表了一种特殊形式的血源性或全身性接触型皮炎，但在过去十年中出现的几篇重要论文均不同意，并建议将BS与血源性或全身性接触型皮炎区分开。提出了新的首字母缩略词SDRIFE（与药物相关的对称性三尖瓣和屈曲性皮疹），并提出了五个诊断标准：（1）在首次或重复给药时暴露于全身性给药（不包括接触性过敏原），（2）腹股沟/肛周区和/或腹股沟/生殖器区的V型红斑明显划定为红斑，（3）至少有另外3个间曲折/屈折，（4）患处对称，（5）不存在全身症状和体征。尽管支持SDRIFE的论点是有道理的，但我们中的许多人仍然更喜欢使用更聪明的名称狒狒综合症，甚至更多的作者同时使用这两个术语。我们承认，我们很难放弃BS一词，多年来一直为我们服务得很好。但是，对这种药疹形式的特征的认识，熟悉和知识必须取代对某种命名法的情感依恋，因此，无论多么勉强，我们都必须接受改变。

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