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Obesity and the metabolic syndrome in pediatric psoriasis

机译：肥胖与小儿牛皮癣的代谢综合征

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Psoriasis is a common, chronic inflammatory dermatosis that often has its onset during childhood. There is increasing evidence that psoriasis in adults is associated with obesity, the metabolic syndrome, and associated comorbidities, including insulin resistance/type 2 diabetes, dyslipidemia, hypertension, and cardiovascular disease. This association is postulated to arise, at least in part, as a result of a systemic proinflammatory state that is mediated by adipose tissue. Several recent observational studies suggest that children and adolescents with psoriasis may be at increased risk of being overweight and obese as well as having an increased risk for features of the metabolic syndrome. Such an association raises concern with regards to the long-term health implications for children and adolescents with psoriasis and suggests that better awareness, evaluation, and management of overweight and obese patients and associated metabolic disease are warranted in this population. (C) 2015 Elsevier Inc. All rights reserved.
机译：牛皮癣是一种常见的慢性炎症性皮肤病，通常在儿童时期就发作。越来越多的证据表明，成年人的牛皮癣与肥胖，代谢综合征和相关合并症有关，包括胰岛素抵抗/ 2型糖尿病，血脂异常，高血压和心血管疾病。推测这种关联至少部分地是由于由脂肪组织介导的全身性促炎状态而引起的。最近的几项观察性研究表明，患有牛皮癣的儿童和青少年可能会增加超重和肥胖的风险，并可能增加代谢综合征的特征。这种关联引起了人们对牛皮癣儿童和青少年的长期健康影响的关注，并建议在这一人群中对超重和肥胖患者以及相关的代谢性疾病有更好的认识，评估和管理。 （C）2015 Elsevier Inc.保留所有权利。

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