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首页> 外文期刊>Journal of neurology >CSF neurofilament protein analysis in the differential diagnosis of ALS.
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CSF neurofilament protein analysis in the differential diagnosis of ALS.

机译：脑脊液神经丝蛋白分析在ALS的鉴别诊断中。

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BACKGROUND: Cerebrospinal fluid (CSF) biomarkers have been studied to differentiate between patients with ALS and neurological controls, but not in comparison to clinically more relevant disorders mimicking ALS. METHODS: In this retrospective study, CSF concentrations of various brain-specific proteins were analyzed in patients with ALS (n = 32) and ALS-mimic disorders (n = 26). RESULTS: CSF concentrations of neurofilament light (NFL) and heavy chain (NFHp35), but not other brain-specific proteins, were significantly higher in patients with ALS than in patients with an ALS-mimic disorder, however with maximum sensitivity or specificity of 80%. The mean CSF level of NFHp35 was 781 ng/L in the ALS group vs. 338 ng/L in the ALS-mimic disorders group and for NFL the mean CSF levels were 62 ng/L vs. 24 ng/L. CONCLUSION: Although CSF concentrations of NFL and NFHp35 are higher in patients with ALS, the diagnostic accuracy for differentiating ALS from ALS-mimic disorders seems insufficient. Our results suggest that, in the clinical work-up of patients suspected of ALS, application of CSF analysis alone is limited but may have potential in combination with other clinical and electrophysiological markers.
机译：背景：已经研究过脑脊液（CSF）生物标志物以区分ALS患者和神经控制患者，但与临床上更相关的模仿ALS的疾病相比却没有。方法：在这项回顾性研究中，分析了ALS（n = 32）和ALS-拟态障碍（n = 26）患者的各种脑特异性蛋白的CSF浓度。结果：ALS患者的CSF中神经丝轻链（NFL）和重链（NFHp35）的浓度显着高于其他ALS模拟障碍患者，但最大敏感性或特异性为80 ％。 ALS组的NFHp35的平均CSF水平为781 ng / L，而ALS模仿障碍组为338 ng / L，而NFL的CSF的平均水平为62 ng / L对24 ng / L。结论：尽管ALS患者脑脊液中NFL和NFHp35的浓度较高，但将ALS与ALS模拟障碍区分开的诊断准确性似乎不足。我们的结果表明，在怀疑ALS的患者的临床检查中，仅CSF分析的应用是有限的，但与其他临床和电生理标志物结合使用可能具有潜力。

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