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首页> 外文期刊>Journal of neurology >Elevated plasma homocysteine levels in patients with multiple sclerosis are associated with male gender
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Elevated plasma homocysteine levels in patients with multiple sclerosis are associated with male gender

机译：多发性硬化症患者血浆同型半胱氨酸水平升高与男性相关

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摘要

Elevated homocysteine (Hcy) levels exert several neurotoxic actions and vascular dysfunctions that may be involved in pathogenesis and progression of multiple sclerosis (MS). The effective role of Hcy in MS however remains to be determined. The aim of this work was to compare plasma Hcy levels in MS patients and neurological disease controls (NDC) and to evaluate their relationships with clinical and demographic variables. In this cross-sectional study, we examined plasma Hcy levels in 217 patients with MS [53 clinically isolated syndromes (CIS) suggestive of MS, 134 relapsing remitting (RR), 23 secondary progressive (SP) and seven primary progressive (PP) MS], recruited among patients attending a tertiary clinical center in southern Italy and in 219 age/sex-matched controls. Median Hcy levels were slightly higher in MS patients compared to NDC (9.1 lmol/l; range, 3.4-35.9 vs. 8.6, range 3.5-27.4; p = 0.02). Median Hcy concentrations were increased in males more than in females in the MS population (10.4 vs. 8.4; p<0.0001), whereas no differences across genders were found in NDC (9.1 vs. 8.5). Hcy levels were higher in male MS patients compared to the male NDC patients (p = 0.001). Patients with CIS had lower Hcy (7.5 lmol/l; p = 0.004) compared to patients with RR (9.5 lmol/l), SP (10.1 lmol/l) and PP (9.9 lmol/l). Median Hcy concentration was higher in patients with disease duration longer than 22 months (9.7 vs. 8.6 lmol/l; p = 0.02). Plasma Hcy levels are increased in patients with definite MS. Higher Hcy levels are associated with male sex, suggesting a role of Hcy in neurodegenerative processes of MS, which are prominent in male patients.
机译：同型半胱氨酸（Hcy）水平升高会发挥多种神经毒性作用和血管功能障碍，可能与多发性硬化症（MS）的发病机理和进展有关。然而，Hcy在MS中的有效作用尚待确定。这项工作的目的是比较MS患者和神经系统疾病对照（NDC）的血浆Hcy水平，并评估其与临床和人口统计学变量之间的关系。在这项横断面研究中，我们检查了217例MS患者的血浆Hcy水平[53例提示MS的临床孤立综合征（CIS），134例复发缓解（RR），23例继发进行性（SP）和7例原发进行性（PP）MS ]，这些患者是在意大利南部一家三级临床中心和219位年龄/性别匹配的对照组中接受研究的患者中招募的。与NDC相比，MS患者的Hcy中位数略高（9.1 lmol / l;范围3.4-35.9与8.6，范围3.5-27.4; p = 0.02）。在MS人群中，男性中位数Hcy升高高于女性（10.4 vs. 8.4; p <0.0001），而在NDC中未发现性别差异（9.1 vs. 8.5）。与男性NDC患者相比，男性MS患者的Hcy水平更高（p = 0.001）。与RR（9.5 lmol / l），SP（10.1 lmol / l）和PP（9.9 lmol / l）相比，CIS患者的Hcy（7.5 lmol / l; p = 0.004）较低。疾病持续时间超过22个月的患者的Hcy浓度中位数更高（9.7对8.6 lmol / l; p = 0.02）。确诊MS的患者血浆Hcy水平升高。较高的Hcy水平与男性相关，这表明Hcy在MS的神经退行性过程中发挥作用，这在男性患者中尤为突出。

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