NMDA receptor autoantibodies in sporadic Creutzfeldt-Jakob disease.

Graham Mackay; Kate Ahmad; Jon Stone; Cathie Sudlow; David Summers; Richard Knight; Robert Will; Sarosh R Irani; Angela Vincent; Paul Maddison

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NMDA receptor autoantibodies in sporadic Creutzfeldt-Jakob disease.

机译：散发性克雅氏病中的NMDA受体自身抗体。

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Sporadic Creutzfei'd|-Jakob disease (sCJD) and TV-methyl-D-aspartate receptor antibody (NMDAR-Ab) encephalitis [1], share similar clinical features including prominent psychiatric symptoms, memory problems, and seizures (Table 1). Previously, other forms of autoimmune encephalitis have been misdiagnosed as CJD, including Hashimoto's and voltage-gated potassium channel complex antibody-associated encephalopathies [2, 3]. Here, conversely, we describe two patients presenting with progressive cognitive impairment and NMDAR-Abs with confirmed sCJD at post mortem.

机译：偶发性Creutzfei'| -Jakob病（sCJD）和TV-甲基-D-天门冬氨酸受体抗体（NMDAR-Ab）脑炎[1]，具有相似的临床特征，包括明显的精神症状，记忆障碍和癫痫发作（表1）。以前，其他形式的自身免疫性脑炎被误诊为CJD，包括桥本氏病和电压门控钾通道复合物抗体相关性脑病[2，3]。相反，在这里，我们描述了两名在验尸时表现为进行性认知障碍和NMDAR-Abs确诊为sCJD的患者。

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《Journal of neurology》 |2012年第9期|共3页
作者
Graham Mackay; Kate Ahmad; Jon Stone; Cathie Sudlow; David Summers; Richard Knight; Robert Will; Sarosh R Irani; Angela Vincent; Paul Maddison;
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正文语种 eng
中图分类神经病学;
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1. NMDA receptor autoantibodies in sporadic Creutzfeldt-Jakob disease. [J] . Graham Mackay, Kate Ahmad, Jon Stone, Journal of neurology . 2012,第9期

机译：散发性克雅氏病中的NMDA受体自身抗体。
2. Ultrastructural study of florid plaques in variant Creutzfeldt-Jakob disease: a comparison with amyloid plaques in kuru, sporadic Creutzfeldt-Jakob disease and Gerstmann-Straussler-Scheinker disease. [J] . Sikorska B, Liberski PP, Sobow T, Neuropathology and applied neurobiology . 2009,第1期

机译：变种Creutzfeldt-Jakob病中的小斑块的超微结构研究：与库鲁，散发性Creutzfeldt-Jakob病和Gerstmann-Straussler-Scheinker病中淀粉样斑块的比较。
3. NMDA Receptor Autoantibodies in Autoimmune Encephalitis Cause a Subunit-Specific Nanoscale Redistribution of NMDA Receptors [J] . Laurent Ladépêche, Jesús Planagumà, Shreyasi Thakur, Cell Reports . 2018,第13期

机译：自身免疫性脑炎中的NMDA受体自身抗体导致NMDA受体亚基特异性纳米级重新分布。
4. EFFECTS OF NMDA AND NON-NMDA RECEPTORS ANTAGONISTS ON THE BEHAVIOR OF CULTURED CORTICAL NETWORKS [C] . Laura Bonzano, Marco Bove, Sergio Martinoia Brain Inspired Cognitive Systems . 2004

机译：NMDA和非NMDA受体对拮抗剂对培养皮质网络行为的影响
5. Experience-dependent regulation of presynaptic NMDA receptors (preNMDARs) and their role in neurotransmission and synaptic plasticity. [D] . Corlew, Rebekah. 2009

机译：经验依赖的突触前NMDA受体（preNMDARs）的调节及其在神经传递和突触可塑性中的作用。
6. Stereotypic Movements in Case of Sporadic Creutzfeldt-Jakob Disease: Possible Role of Anti-NMDA Receptor Antibodies [O] . Michelle Molina, Robert Fekete 2012

机译：偶发性Creutzfeldt-Jakob病的刻板印象运动：抗NMDA受体抗体的可能作用
7. Autoantibodies in sporadic Creutzfeldt-Jakob disease. [O] . Angus-Leppan, H, Rudge, P, Mead, S, 2013

机译：偶发性Creutzfeldt-Jakob病的自身抗体。

NMDA receptor autoantibodies in sporadic Creutzfeldt-Jakob disease.

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