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Narcolepsy: Environment, genes and treatment

机译:发作性睡病:环境,基因和治疗

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摘要

Narcolepsy is a central sleep disorder typically involving symptoms of daytime somnolence, unintentional lapses into sleep, sleep paralysis and frequent nocturnal awakenings. The disorder involves a dissociated sleep-wake cycle with rapid eye movement (REM) sleep intruding into wakefulness. Narcolepsy with cataplexy (type 1 narcolepsy) is caused by loss of hypocretin-secreting neurons, decreasing CSF levels of this neuropeptide. Mean prevalence is believed to be 30/100,000, with the highest rates observed in Japan and the lowest in Saudia Arabia. Age at onset is typically 10-30 years, peaking at 15 years and rarely presenting <10 years and >40 years of age.
机译:发作性睡病是一种中枢性睡眠障碍,通常涉及白天的嗜睡,无意地进入睡眠,睡眠麻痹和频繁的夜间觉醒的症状。该疾病涉及游离的觉醒周期,而快速的眼动(REM)睡眠会进入觉醒状态。患有发作性猝倒的发作性睡病(1型发作性睡病)是由分泌分泌降钙素的神经元引起的,从而降低了该神经肽的CSF水平。据信,平均患病率为30 / 100,000,其中日本的患病率最高,而沙特阿拉伯的患病率最低。发病年龄通常为10-30岁,在15岁时达到高峰,很少出现<10岁和> 40岁。

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