Identification of anti-Sez612 antibody in a patient with cerebeilar ataxia and retinopathy

Hiroaki Yaguchi; Ichiro Yabe; Hidehisa Takahashi; Fumihiko Okumura; Akiko Takeuchi; Kazuhiro Horiuchi; Takahiro Kano; Atsuhiro Ka * Wataru Saito; Masaki Matsumoto; Keiichi I. Nakayama; SMgetsugu Hatakeyama; Hidenao Sasaki

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Identification of anti-Sez612 antibody in a patient with cerebeilar ataxia and retinopathy

机译：小脑共济失调和视网膜病变患者抗Sez612抗体的鉴定

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Cerebeilar ataxia (CA) is one of the main syndromes of both central nervous system syndrome associated with neuronal surface antibodies and paraneoplastic neurological diseases [5]. Some antigens of anti-neuronal antibodies have been reported, and their detection has contributed to the establishment of the disease concept and treatment strategy [1]. In the present study, in order to identify novel anti-neuronal antibodies and the corresponding autoanti-gens, we examined sera from six patients assumed to have immune-mediated cerebeilar ataxia for immunoreactivity against the mouse cerebellum.

机译：小脑共济失调（CA）是与神经元表面抗体和副肿瘤性神经系统疾病相关的中枢神经系统综合征的主要综合征之一[5]。已经报道了一些抗神经元抗体的抗原，其检测有助于疾病概念和治疗策略的建立[1]。在本研究中，为了鉴定新的抗神经元抗体和相应的自身抗原，我们检查了六名被假定具有免疫介导的小脑共济失调患者的血清对小鼠小脑的免疫反应性。

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《Journal of neurology》 |2014年第1期|共3页
作者
Hiroaki Yaguchi; Ichiro Yabe; Hidehisa Takahashi; Fumihiko Okumura; Akiko Takeuchi; Kazuhiro Horiuchi; Takahiro Kano; Atsuhiro Ka * Wataru Saito; Masaki Matsumoto; Keiichi I. Nakayama; SMgetsugu Hatakeyama; Hidenao Sasaki;
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中图分类神经病学;
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1. Identification of anti-Sez612 antibody in a patient with cerebeilar ataxia and retinopathy [J] . Hiroaki Yaguchi, Ichiro Yabe, Hidehisa Takahashi, Journal of neurology . 2014,第1期

机译：小脑共济失调和视网膜病变患者抗Sez612抗体的鉴定
2. Glutamate receptor antibodies in neurological diseases: anti-AMPA-GluR3 antibodies, anti-NMDA-NR1 antibodies, anti-NMDA-NR2A/B antibodies, anti-mGluR1 antibodies or anti-mGluR5 antibodies are present in subpopulations of patients with either: epilepsy, encephalitis, cerebellar ataxia, systemic lupus erythematosus (SLE) and neuropsychiatric SLE, Sjogren's syndrome, schizophrenia, mania or stroke. [J] . Mia Levite Journal of neural transmission . 2014,第8期

机译：神经系统疾病中的谷氨酸受体抗体：患有以下疾病的患者的亚群中存在抗AMPA-GluR3抗体，抗NMDA-NR1抗体，抗NMDA-NR2A / B抗体，抗mGluR1抗体或抗mGluR5抗体。脑炎，小脑性共济失调，系统性红斑狼疮（SLE）和神经精神病性SLE，干燥综合征，精神分裂症，躁狂症或中风。
3. Identification of a novel homozygous SPG7 mutation in a Japanese patient with spastic ataxia: Making an efficient diagnosis using exome sequencing for autosomal recessive cerebellar ataxia and spastic paraplegia [J] . DoiH., OhbaC., TsurusakiY., Internal medicine. . 2013,第14期

机译：在日本患有痉挛性共济失调的患者中新的纯合子SPG7突变的鉴定：使用外显子组测序对常染色体隐性小脑共济失调和痉挛性截瘫进行有效诊断
4. Automated Evaluation of Upper Limb Motor Impairment of Patient with Cerebellar Ataxia [C] . Ha Tran, Pubudu N. Pathirana, Malcolm Horne, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2019

机译：小脑性共济失调患者上肢运动障碍的自动评估
5. Investigating Molecular Mechanisms Underlying Mild Phenotype in Friedreich Ataxia Patients with G130V Missense Mutation [D] . Clark, Elisia. 2018

机译：Friedreich共济失调患者G130V错义突变的轻度表型背后的分子机制的调查。
6. Cerebellar Ataxia Followed by Stiff Person Syndrome in a Patient with Anti-GAD Antibodies [O] . Sinali O. Seneviratne, Katherine A. Buzzard, Belinda Cruse, 2020

机译：抗GAD抗体患者的小脑共济失调继之以僵硬的人综合症
7. Identification of a Novel Homozygous SPG7 Mutation in a Japanese Patient with Spastic Ataxia: Making an Efficient Diagnosis Using Exome Sequencing for Autosomal Recessive Cerebellar Ataxia and Spastic Paraplegia [O] . Hiroshi Doi, Chihiro Ohba, Yoshinori Tsurusaki, 2013

机译：用痉挛性共济失息鉴定日本患者中的新型纯合的纯合纯合并的突变：使用Exome测序进行常染色体隐性小脑共济失调和痉挛性截瘫的高效诊断
8. Identification of Auto-Antibodies to Breast Cancer Antigens in Breast Cancer Patients [R] . Novinger, L., Krag, D., Shukla, G. 2009

机译：乳腺癌患者乳腺癌抗原自身抗体的鉴定

Identification of anti-Sez612 antibody in a patient with cerebeilar ataxia and retinopathy

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